Secretion of Wnts is dispensable for hematopoiesis.

Blood
Robert A J Oostendorp

Abstract

In this issue of Blood, Kabiri and coworkers report the hematopoietic deletion of the endoplasmic reticulum–localized O-acyltransferase porcupine (PORCN), which is necessary for acylation of Wnts in the endoplasmic reticulum, enabling their secretion and binding to the frizzled receptors. Unexpectedly, the absence of secreted Wnt factors does not have major effects on steady-state in vivo hematopoiesis or on long-term repopulating activity of Wnt-deficient hematopoietic stem cells.

References

Jun 24, 2000·European Journal of Biochemistry·K TanakaT Kadowaki
Oct 11, 2011·Cell Stem Cell·Tiago C LuisFrank J T Staal
Jul 13, 2012·Differentiation; Research in Biological Diversity·Rani NajdiMarian L Waterman
Oct 22, 2013·Nature·Maria Carolina FlorianHartmut Geiger

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Citations

Mar 27, 2016·Experimental Hematology·Frank J T StaalHarald Mikkers

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