Secretion patterns of circulating osteoprotegerin and response to acute and chronic energy deprivation in young healthy adults.

The Journal of Clinical Endocrinology and Metabolism
Konstantinos N AronisChristos S Mantzoros

Abstract

Osteoprotegerin (OPGN) is a bone-remodeling marker that is associated with various metabolic and vascular complications. Cross-sectional studies in humans have demonstrated an inverse association between leptin, a marker of energy sufficiency, and OPGN. The physiology of OPGN has not been fully elucidated to date. We thus aim to elucidate 1) whether OPGN levels exhibit any gender dimorphism or day/night secretion pattern; and 2) whether there is any effect of acute and/or chronic energy deprivation on its circulating levels and whether such effects are mediated through leptin. Study A: To evaluate OPGN secretion patterns and OPGN response to acute energy deprivation, we studied 12 healthy subjects under three different conditions for 72 h-in the isocaloric fed state, and during a fasting state with administration of either placebo or metreleptin in replacement doses. Blood samples were obtained every 15 min and pooled hourly during the last 24 h of the study. Study B: To evaluate the effect of chronic energy deprivation on OPGN secretion, we measured its levels in 14 obese subjects before and during weight loss after bariatric surgery. OPGN levels exhibited a statistically significant (P < 0.01), albeit clinically limited in ma...Continue Reading

References

Mar 31, 1999·European Journal of Endocrinology·A Schlemmer, C Hassager
Apr 10, 1999·Clinical Endocrinology·C S Mantzoros, S J Moschos
Jan 17, 2002·Bone·N H BjarnasonC Christiansen
May 3, 2003·The Journal of Clinical Investigation·Jean L ChanChristos S Mantzoros
Aug 6, 2003·Journal of Neuroendocrinology·J M MullingtonC S Mantzoros
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·Madhusmita MisraAnne Klibanski
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·K E NaylorA Blumsohn
Feb 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Steven A SheaChristos S Mantzoros
Nov 9, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R TarquiniF Halberg
May 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean L ChanChristos S Mantzoros
Sep 19, 2006·International Journal of Pharmaceutics·Daniel R VegaMaría Reinoso
Jun 7, 2007·The Journal of Clinical Endocrinology and Metabolism·F JosephW D Fraser
Aug 19, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A DovioA Angeli
Sep 27, 2007·The Journal of Clinical Endocrinology and Metabolism·Damaris VegaKhashayar Sakhaee
May 1, 2008·The Journal of Clinical Endocrinology and Metabolism·Jean L ChanChristos S Mantzoros
Dec 5, 2008·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H M TerekeciM Ozata
Jan 30, 2009·The American Journal of Clinical Nutrition·Susann Blüher, Christos S Mantzoros
Apr 7, 2009·Bone·Kim HenriksenMorten A Karsdal
Jan 20, 2010·Annals of Internal Medicine·Theodore KelesidisChristos S Mantzoros
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Frank A J L ScheerSteven A Shea
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Naoyuki TakahashiYasuhiro Kobayashi
Mar 18, 2011·The Journal of Clinical Endocrinology and Metabolism·S BoonenM McClung
Jul 12, 2011·Metabolism: Clinical and Experimental·Elizabeth SienkiewiczChristos S Mantzoros
Jul 12, 2011·Metabolism: Clinical and Experimental·Catherine M Gordon
Aug 4, 2011·Hormone Research in Pædiatrics·Paul Baldock
Jul 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christos S MantzorosAnastasia Koniaris
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Maria T VamviniChristos S Mantzoros
Sep 17, 2011·Current Medicinal Chemistry·P GrigoropoulouN Tentolouris
Nov 5, 2011·European Journal of Clinical Investigation·Ana M Blázquez-MedelaCarlos Martínez-Salgado
Nov 15, 2011·Annual Review of Physiology·Gerard Karsenty, Franck Oury

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