Secretoglobin and Transferrin Expression in Bronchoalveolar Lavage Fluid of Horses with Chronic Respiratory Disease

Journal of Veterinary Internal Medicine
M Miskovic FeutzR E Raskin

Abstract

Lower expression of secretoglobin and transferrin has been found in the bronchoalveolar lavage fluid (BALF) of a small number of horses with experimentally induced signs of recurrent airway obstruction (RAO) compared to healthy controls. Secretoglobin and transferrin BALF expression will be similarly decreased in horses with naturally occurring clinical signs of RAO and in horses with experimentally induced clinical signs of RAO as compared to healthy controls and intermediate in horses with inflammatory airway disease (IAD). Recurrent airway obstruction-affected and control horses were subjected to an experimental hay exposure trial to induce signs of RAO. Client-owned horses with a presumptive diagnosis of RAO and controls from the same stable environments were recruited. Pulmonary function and BALF were evaluated from control and RAO-affected research horses during an experimental hay exposure trial (n = 5 in each group) and from client-owned horses (RAO-affected horses, n = 17; IAD-affected horses, n = 19; healthy controls, n = 5). The concentrations of secretoglobin and transferrin in BALF were assessed using Western blots. Naturally occurring and experimentally induced RAO horses had similar decreases in BALF transferrin ...Continue Reading

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Citations

May 18, 2019·Journal of Veterinary Internal Medicine·Clementine GyJean-Pierre Lavoie
Jun 23, 2020·Journal of Proteomics·Elisabetta Chiaradia, Ingrid Miller

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Methods Mentioned

BETA
bronchoalveolar
lavage
sedation
bronchoalveolar lavage

Software Mentioned

ImageJ

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