Secretory activity in the floor plate neuroepithelium of the developing human spinal cord: morphological evidence

The Anatomical Record
O TanakaH Shinohara

Abstract

The developing spinal cord at the cervical and thoracic levels in 14 human embryos ranging from Carnegie stages 14 to 20 were examined with the electron microscope. The floor plate-forming cells contained numerous cytoplasmic organelles, such as rough endoplasmic reticulum (ER), Golgi apparatus, and well-developed junctional complexes between the adjacent cells. Microvilli and cilia were numerous at the apical surface of neuroepithelial cells in the floor plate, but few were found in the lateral walls. Periodic acid-Schiff-positive substances were predominantly present in the neuroepithelial cells of the floor plate. In all specimens examined, multivesicular structures were observed in the floor plate neuroepithelium, but not in other regions of the spinal cord. The number of multivesicular structures appeared to increase with embryonic age. These structures contained numerous small and translucent vesicles within an electron-dense matrix; most vesicles were 40-70 nm in diameter. It appeared that the envelope of the multivesicular structures was first formed by the fusion of smooth ER-like cisterns, followed by invagination of the envelope by the vesicular contents. Presumably, the mature multivesicular structures were subseque...Continue Reading

References

May 1, 1978·The American Journal of Anatomy·J C Herr, P M Heidger
Jan 1, 1967·International Review of Cytology·P B Gahan
Dec 1, 1981·The Journal of Cell Biology·D F Bainton
Sep 25, 1957·The Journal of Biophysical and Biochemical Cytology·J B CAULFIELD

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Citations

Mar 12, 2008·Brain Research Bulletin·Isabelle BachyMarion Wassef
Mar 10, 2001·Microscopy Research and Technique·M A del BrioE M Rodríguez

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