Secretory carcinoma of male breast: case report and review of the literature.

International Journal of Breast Cancer
S Gabal, S Talaat

Abstract

Secretory carcinoma is a rare low-grade breast carcinoma, initially termed "juvenile breast cancer," but it is now known to occur in adults of both sexes. It is the only epithelial tumor of the breast with a balanced translocation, t(12;15), that creates an ETV6-NTRK3 gene translocation. In this paper, a 19-year-old male patient has had a right breast mass for 9 years which suddenly increased in size with no evidence of palpable axillary lymph nodes. The mass was excised for frozen section and was diagnosed as malignant growth for simple mastectomy. Microscopic examination revealed the classical features of secretory carcinoma. The tumor cells were positive for EMA and S-100 protein and focally positive for cytokeratin and ER but negative for progesterone receptor, CD34, and CEA. Four months later the patient developed ipsilateral axillary lymph node enlargement, with lymph node metastases in five of the dissected 19 lymph nodes. The patient was treated with six courses of chemotherapy and radiotherapy. Conclusion. Though considered an indolent neoplasm, secretory carcinoma does metastasize to lymph nodes. Surgery in the form of mastectomy with axillary clearance is the treatment of choice. This paper includes a rare case repor...Continue Reading

References

Oct 1, 1977·Pathology·J J SullivanK J Donald
Aug 1, 1985·Journal of Pediatric Surgery·S R KarlR Zaino
May 1, 1980·Cancer·F A Tavassoli, H J Norris
Feb 1, 1994·Social Science & Medicine·R V Clarke, B Poyner
Nov 3, 1998·Journal of Clinical Pathology·H KuwabaraS Okada
Feb 10, 1999·Pathology International·K KameyamaJ Hata
Jul 10, 1999·Pathology·B S Bhagwandeen, L Fenton
Dec 6, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H HerzD Goldstein
Aug 9, 2002·Annals of Surgical Oncology·Eelco de BreeDimitris D Tsiftsis
Apr 22, 2004·Genes, Chromosomes & Cancer·Nikita MakretsovDavid G Huntsman
Jun 4, 2004·World Journal of Surgical Oncology·Alfie J KavalakatTerence B Culas
Jul 29, 2004·Journal of Clinical Pathology·S R NivedithaA Nangia
Feb 8, 2005·The Breast : Official Journal of the European Society of Mastology·F GrabellusK A Metz

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Citations

Apr 5, 2016·Journal of Surgical Oncology·John Doromal JacobVicki Suzanne Klimberg
Jul 27, 2012·Annals of Diagnostic Pathology·Nasir Ud DinNaila Kayani
Sep 27, 2018·The Breast Journal·Jared W GarlickCindy B Matsen
Aug 31, 2021·Virchows Archiv : an International Journal of Pathology·L CimaM P Foschini

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Methods Mentioned

BETA
dissection
biopsy

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