Secretory carcinoma of salivary type in a lymph node presenting as a neck cyst diagnosed by cytology: A case report.

Diagnostic Cytopathology
Jan HrudkaPavel Dundr

Abstract

Secretory carcinoma (SC) is a relatively recently described salivary gland adenocarcinoma characterized by ETV6-NTRK3 gene fusion and, in most cases, indolent clinical behavior. Morphologically, the tumor shows a glandular architecture and the presence of monophasic tumor cells with vacuolated cytoplasm, low-grade nuclear atypia, and mucin production, with possibly a tubular, papillary, or cystic arrangement. In this article, we describe a case of a 52-year old man with SC involving a neck lymph node clinically manifesting as a slowly growing cystic neck mass without recent proof of the primary tumor, but with a history of a parotid gland "cystadenopapilloma," which had been removed 35 years prior. A fine-needle aspiration biopsy revealed a diagnosis of SC. Subsequent histopathological examination after lymph node dissection confirmed the diagnosis. The tumor showed typical features of SC, including immunohistochemical positivity for NTRK and NTRK3 gene rearrangement, detected using in situ hybridization. We discuss that the tumor may be a late metastasis occurring 35 years after resection of undiagnosed salivary SC or a primary SC arising from heterotopic salivary tissue within a lymph node. Differential diagnostic considerati...Continue Reading

References

Mar 1, 1980·Cancer·K H Perzin, V A Livolsi
Oct 9, 2012·Cancer Cytopathology·Justin A BishopSyed Z Ali
Dec 12, 2012·Cancer Cytopathology·Christopher C GriffithRaja R Seethala
Mar 22, 2014·Diagnostic Cytopathology·Maiko TakedaChiho Ohbayashi
Aug 5, 2014·Diagnostic Cytopathology·Min Jung JungKyung-Ja Cho
Sep 12, 2014·CytoJournal·T Danielle SamulskiZubair Baloch
Jun 20, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Todd M StevensMargaret Brandwein-Gensler
Nov 8, 2015·American Journal of Otolaryngology·S Craig QuattlebaumKenny Chan
Dec 24, 2015·Case Reports in Otolaryngology·Fatemah FarasMutlaq K Al-Sihan
Aug 31, 2016·Archives of Pathology & Laboratory Medicine·Vishwas Parekh, Todd M Stevens
Mar 3, 2017·Diagnostic Cytopathology·Paula A Rodríguez-UrregoOscar Lin
May 4, 2017·European Annals of Otorhinolaryngology, Head and Neck Diseases·C MartinJ-M Prades
Dec 7, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Ethar Al-HusseinawiEvanthia Omoscharka
Jul 25, 2019·Radiology Case Reports·Karisma GuptaChristopher M Lack

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.