Secretory component and immunoglobulins in the intrahepatic biliary tree and peribiliary gland in normal livers and hepatolithiasis

Gastroenterologia Japonica
H Sugiura, Yasuni Nakanuma

Abstract

Distribution of secretory component (SC), IgA, IgM and joining chain (J chain) in the intrahepatic biliary epithelium and peribiliary glandular epithelium were studied in normal livers and hepatolithiasis. In normal livers, SC was immunohistochemically demonstrated homogeneously in the cytoplasm of the biliary lining and peribiliary glandular epithelium. Immunoelectron-microscopically, SC was localized in the basolateral plasma membranes, nuclear membranes, rough endoplasmic reticulums, Golgi complexes and intracytoplasmic small vesicles, suggesting that the biliary lining and peribiliary glandular epithelium has an ability to synthesize SC. On the other hand, IgA and IgM were found heterogeneously in the biliary lining epithelium, and immunoelectron-microscopically they were only localized in the basolateral plasma membranes and vesicles. J chain was found in similar portions, suggesting that IgA and IgM in biliary lining and glandular epithelium were polymeric. It seems likely that polymeric IgA and IgM combine with SC on the biliary lining and glandular epithelial membranes, and subsequent endocytic transport and secretion of these complexes into the bile occur. In hepatolithiasis in which biliary living epithelia are hyperp...Continue Reading

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Citations

Jan 1, 1994·Journal of Gastroenterology and Hepatology·Y NakanumaK Harada
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K TsuneyamaY Nakanuma
Oct 13, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenichi Harada, Yasuni Nakanuma
Aug 28, 2010·Mediators of Inflammation·Kenichi Harada, Yasuni Nakanuma
May 1, 1992·Digestive Diseases and Sciences·J Y SungE A Shaffer
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KatayanagiM E Gershwin
Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kenichi HaradaYasuni Nakanuma
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M SasakiH Kurumaya
Nov 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kenichi HaradaYasuni Nakanuma
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·N KannoG Alpini
Oct 14, 2011·International Journal of Hepatology·Kenichi Harada, Yasuni Nakanuma
Jan 1, 1994·Journal of Gastroenterology and Hepatology·Y NakanumaK Saito

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