Secretory effects of gastric inhibitory polypeptide on the isolated perfused porcine pancreas

Acta Physiologica Scandinavica
S L JensenK B Lauritsen

Abstract

The effect of gastric inhibitory polypeptide (GIP) in physiological concentrations (250, 500, 1,000 and 2,000 pg/ml) upon endocrine and exocrine secretion from the isolated perfused porcine pancreas was studied at various glucose concentrations in the perfusate. GIP increased insulin release in a dose-dependent manner. The sensitivity of the beta-cells to GIP was glucose independent. No effect was observed on glucagon or exocrine secretion regardless of the glucose concentration in the perfusate. We conclude that GIP is powerful insulin-stimulator even in low physiological concentrations in the presence of glucose concentrations comparable to those seen during an oral glucose load, which makes GIP to one of the strongest incretin candidates known, i.e. the factor(s) contributing to the augmented insulin response after ingestion of glucose.

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Citations

Jan 1, 1979·Acta Physiologica Scandinavica·J J HolstJ Fahrenkrug
Nov 10, 2007·The Journal of Clinical Investigation·Jean B RegardShaun R Coughlin
Oct 27, 2014·Current Diabetes Reports·Asger LundTina Vilsbøll
Dec 10, 2009·American Journal of Physiology. Endocrinology and Metabolism·Meena AsmarJens Juul Holst
Jan 1, 1986·Journal of the American College of Nutrition·W A ForsytheJ J Anderson

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