PMID: 696858Oct 1, 1978Paper

Secretory effects of secretin on isolated perfused porcine pancreas

The American Journal of Physiology
S L JensenO B Schaffalitzky de Muckadell

Abstract

The effect of pure natural porcine secretin on endocrine and exocrine pancreatic secretion was studied in the totally isolated perfused porcine pancreas. The exocrine pancreatic responses to secretin correspond well with those obtained in the anesthetized pig. The lowest concentration of secretin observed to increase pancreatic secretion was 2.8 pmol/liter, whereas the maximum pancreatic responses were obtained at a secretin concentration of 92 pmol/liter. The infusion of secretin in concentrations ranging from 2.8 to 278 pmol/liter in the presence of a constant concentration of glucose (7.5, 5.0, or 3.5 mmol/liter) was without effect on the insulin and glucagon release. Infusion of secretin at a concentration of 834 pmol/liter in the presence of glucose at 7.5 mmol/liter provoked a significant (P less than 0.01) short-lived increase in insulin secretion. However, there was no effect on the glucagon secretion. The results of this study indicate that neither the augmented insulin response nor the suppression of glucagon elicited by oral glucose depend on secretin.

References

Jan 1, 1977·Scandinavian Journal of Gastroenterology·O B Schaffalitzky de MuckadellJ J Holst
Apr 1, 1967·The Journal of Clinical Investigation·R H UngerA M Eisentraut
Jul 1, 1972·The Journal of Clinical Investigation·F SanteusanioR H Unger
Oct 1, 1971·The Journal of Clinical Investigation·J Iversen
Mar 1, 1970·The Journal of Clinical Investigation·E W KraegenL Lazarus
Dec 1, 1970·The Journal of Clinical Investigation·R L Lerner, D Porte
Apr 1, 1968·Acta Endocrinologica·T Deckert
Dec 1, 1967·The Journal of Clinical Investigation·M J Perley, D M Kipnis
Jun 1, 1963·Acta Physiologica Scandinavica·L LUNDHOLMN VAMOS

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Citations

Feb 6, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Ida M ModvigJens J Holst

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