PMID: 9541602Apr 29, 1998Paper

Secretory immune system of the duck (Anas platyrhynchos). Identification and expression of the genes encoding IgA and IgM heavy chains

European Journal of Immunology
Katharine E MagorD A Higgins

Abstract

IgA has not previously been identified in waterfowl. Studies instead revealed physical and antigenic similarities between duck bile immunoglobulin (Ig) and serum IgM. Here, a differential screening approach was used to clone, from a duck spleen library, the cDNA encoding the heavy (H) chains of IgM and the Ig, identified here as IgA, occurring in duck secretions. Phylogenetic comparisons of inferred amino acid sequences of entire H chain constant (C) regions and of individual domains revealed that the duck mu chain was closest to chicken mu (54% overall identity), and duck alpha was closest to chicken alpha (50% identity). Comparison of the mu and alpha C regions revealed areas of up to 65% amino acid similarity within the C4 domains, accounting for the previously noted antigenic overlap of duck IgM and IgA. Messages for alpha and mu were detected in duck lymphoid organs but the alpha message was most abundant in the respiratory, alimentary and reproductive tracts. The alpha message first appeared around 14 days of age and reached adult levels of expression only at 35-50 days. The results indicate that the duck has a mucosal immune system which utilizes IgA; however, the delayed expression and secretion of duck IgA explains the...Continue Reading

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Citations

Mar 16, 2000·Developmental and Comparative Immunology·D A HigginsZ V Kounev
Mar 16, 2000·Developmental and Comparative Immunology·D L Suarez, S Schultz-Cherry
Mar 16, 2000·Developmental and Comparative Immunology·A R Jilbert, I Kotlarski
Dec 12, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Katherine Belov, Lars Hellman
Jun 8, 1999·Annual Review of Immunology·G W LitmanJ P Rast
Mar 1, 2012·Developmental and Comparative Immunology·Yi SunYaofeng Zhao
Mar 8, 2011·Developmental and Comparative Immunology·Katharine E Magor
Jun 19, 2007·Veterinary Immunology and Immunopathology·Annalaura ManciaMats L Lundqvist
Feb 28, 2016·Developmental and Comparative Immunology·Tian HuangGengsheng Cao
Sep 10, 2005·Developmental and Comparative Immunology·Mats L LundqvistKatharine E Magor
Aug 7, 2007·Cytogenetic and Genome Research·M R W MacDonaldK E Magor
Apr 25, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tian HuangYaofeng Zhao
Sep 24, 2004·Immunology·Jenny M Woof, Michael A Kerr
Apr 1, 1999·Avian Pathology : Journal of the W.V.P.A·S W ChanD A Higgins
Mar 21, 2002·Scandinavian Journal of Immunology·M KimuraI Moro
Jan 19, 2012·Human Vaccines & Immunotherapeutics·Leslie A ReperantAlbert D M E Osterhaus
Sep 14, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lingxiao LiYaofeng Zhao
Sep 11, 2012·Journal of Animal Science and Biotechnology·Yi SunYaofeng Zhao

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