Secretory patterns of growth hormone during basal periods in man

Metabolism: Clinical and Experimental
M W Stolar, G Baumann

Abstract

Human growth hormone (hGH) concentrations in plasma often fall to levels not detectable by RIA. These so-called basal levels prevail during the greater part of the day. Since hGH is involved in the homeostasis of several metabolic processes, it is important to examine its exact plasma concentration and secretory pattern during basal periods. We used an immunoadsorbent technique to extract hGH from large plasma samples to precisely measure basal hGH concentrations and their variation with time. Blood samples (20 mL) were drawn from 12 normal subjects in the fasted and rested state every 15 minutes over a three-hour period. Plasma hGH levels varied over three orders of magnitude (range, 34 to 60,000 pg/mL). During basal periods, episodes of secretory pulses, of moderate sustained secretion, and of complete secretory inactivity occurred. Women had significantly higher overall hGH levels as well as basal hGH levels than men, but no significant sex difference in the pulse frequency during basal periods could be detected in the limited time allotted for study. No convincing relationship was noted between variations in plasma glucose and the secretory pattern of hGH, or vice versa. We conclude that hGH is secreted in an episodic fashi...Continue Reading

References

Jun 1, 1985·The Journal of Clinical Endocrinology and Metabolism·G BaumannK Amburn
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·T J Merimee, S E Fineberg
Feb 5, 1968·Annals of the New York Academy of Sciences·H M Goodman
Dec 1, 1969·The Journal of Clinical Investigation·A L TaylorD H Mintz
Mar 1, 1970·The Journal of Clinical Endocrinology and Metabolism·S Refetoff, P H Sönksen
May 1, 1970·The Journal of Clinical Endocrinology and Metabolism·M H MacGillivrayJ Doe
Nov 1, 1982·The Journal of Clinical Endocrinology and Metabolism·P R Bratusch-MarrainR A DeFronzo

❮ Previous
Next ❯

Citations

Apr 5, 1990·The New England Journal of Medicine·S Melmed
Jun 27, 2006·British Journal of Sports Medicine·M SaugyP Mangin
Jan 7, 2005·The Journal of Clinical Endocrinology and Metabolism·Cacia Soares-WelchJohannes D Veldhuis
Apr 4, 2008·Asian Journal of Andrology·Christer Ehrnborg, Thord Rosén
Aug 1, 2009·Bioanalysis·Chunji He, Moutian Wu
Jul 17, 1987·Journal of Chromatography·J D PearsonD B DeWald
Aug 29, 2007·Pediatric Clinics of North America·Sergio R R Buzzini
Feb 23, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Giselle Fernandes TaboadaMônica Roberto Gadelha
Jan 1, 1993·Ultrasound in Medicine & Biology·E D LehmannR G Gosling
Jul 1, 1988·Clinical Endocrinology·P C HindmarshC G Brook
May 4, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Jin JinTsutomu Hashizume
Oct 5, 2006·The Journal of Clinical Endocrinology and Metabolism·Madalina Ionescu, Lawrence A Frohman
Mar 20, 2001·American Journal of Physiology. Endocrinology and Metabolism·J A GusenoffM R Blackman
Jan 1, 1991·The American Journal of Physiology·M L HartmanJ D Veldhuis
May 31, 2018·Life Sciences·T de Castro BarbosaM T Nunes
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Susan Sam, Lawrence A Frohman
Nov 4, 2021·Journal of Applied Animal Welfare Science : JAAWS·Christian ManteuffelElisa Wirthgen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.