PMID: 8592082Jan 1, 1996Paper

Secretory phospholipase A2 activity is required for permeability barrier homeostasis

The Journal of Investigative Dermatology
M Mao-QiangP M Elias

Abstract

The extracellular bilayers which mediate the epidermal permeability barrier are enriched in ceramides, free fatty acids, and cholesterol. Yet, the epidermal lamellar body, the source of these lipids, is enriched in a more polar mixture; i.e., glucosylceramides and phospholipids, which it delivers to the stratum corneum (SC) interstices. Whereas the extracellular processing of glucosylceramides to ceramides has been shown to be required for barrier homeostasis, the requirement for phospholipid degradation to free fatty acids is not yet established. In this study, we ascertained that topical applications of two chemically unrelated inhibitors of secretory phospholipase A2 (PLA2), bromphenacyl bromide and MJ-33, produced a progressive perturbation in barrier function in intact murine skin, first appearing at 5 d, preceded by the development of epidermal hyperplasia. Moreover, the defect in barrier homeostasis could be reversed by topical co-applications of the nonessential fatty acid, and of palmitic acid, but not by linoleic acid, both products of phospholipid catabolism. Furthermore, the barrier abnormality was accompanied by a reduction in free fatty acid levels in the stratum corneum, while phospholipid levels remained unchang...Continue Reading

References

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Jun 1, 1983·The Journal of Investigative Dermatology·P M Elias

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Citations

Nov 1, 1996·The Journal of Dermatology·P M Elias
Nov 26, 2005·The British Journal of Dermatology·G ValacchiV Bocci
Apr 15, 2008·Annual Review of Biochemistry·Gérard Lambeau, Michael H Gelb
Jun 23, 2011·Dermato-endocrinology·Aegean Chan, Theodora Mauro
Feb 7, 2001·American Journal of Physiology. Cell Physiology·K E Rys-SikoraA P Pentland
Jan 30, 2003·American Journal of Clinical Dermatology·Luisa CoderchJosé L Parra
Sep 24, 2002·The Journal of Biological Chemistry·Sofiane BezzineMichael H Gelb
Dec 28, 2006·Skin Pharmacology and Physiology·E HoubenV Rogiers
Jul 12, 2007·Seminars in Immunopathology·Peter M Elias
Jan 27, 2011·The Journal of Biological Chemistry·Kei YamamotoMakoto Murakami
Oct 5, 2011·The British Journal of Dermatology·J W FluhrJ-P Hachem
May 27, 2016·The Journal of Biological Chemistry·Kei YamamotoMakoto Murakami
Aug 16, 2005·The Journal of Investigative Dermatology·Peter M Elias
Aug 5, 2015·Journal of Clinical Medicine·David J Panther, Sharon E Jacob
Dec 14, 2018·Inflammation and Regeneration·Makoto MurakamiYoshitaka Taketomi
May 28, 2008·International Journal of Cosmetic Science·C R HardingI R Scott
Aug 12, 2004·Biological & Pharmaceutical Bulletin·Makoto Murakami, Ichiro Kudo
Sep 29, 2004·Pharmacology·Izabela Buraczewska, Marie Lodén
Jul 26, 2012·Journal of Lipid Research·Maria BloksgaardSusanne Mandrup
Oct 7, 2015·The Journal of Experimental Medicine·Kei YamamotoMakoto Murakami
Nov 20, 2014·Experimental Dermatology·Peter M Elias
Apr 20, 2000·The Journal of Investigative Dermatology·E MauryH Chap
Jul 10, 2001·The Journal of Investigative Dermatology·J W FluhrP M Elias
Jan 10, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Peter M EliasKenneth R Feingold
Nov 26, 2002·The Journal of Investigative Dermatology·Silke StachowitzHeidrun Behrendt
Jul 4, 2003·The Journal of Investigative Dermatology·Silvia GurrieriMarietta Kaszkin
Jul 26, 2003·The Journal of Investigative Dermatology·Jean-Pierre HachemPeter M Elias
Jul 26, 2003·The Journal of Investigative Dermatology·Piyush KoriaStelios T Andreadis
Oct 22, 2003·Pathologie-biologie·E MauryH Chap
Jun 12, 2004·The Journal of Investigative Dermatology·Joachim W FluhrKenneth R Feingold
May 1, 1996·The Journal of Investigative Dermatology·M Man MQP M Elias
Apr 26, 2003·The Journal of Investigative Dermatology·Joachim W FluhrPeter M Elias

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