Secretory proteins of the endometrium--potential markers for endometrial dysfunction.

Baillière's Clinical Obstetrics and Gynaecology
S C Bell, J O Drife

Abstract

In contrast to our detailed knowledge of endometrial structure, the study of endometrial function is still in its infancy. It seems likely that most of the changes that occur in the endometrium during the cycle are directed towards the promotion of implantation, and that the proteins secreted by the tissue have a role to play in the maintenance of pregnancy. One approach to the study of these proteins has been the incubation of endometrium in vitro with labelled amino acid precursors, and this method has revealed that in early pregnancy two proteins are quantitatively more important than the others synthesized and secreted by the endometrium. One of these proteins is a homologue of beta-lactoglobulin, also known as alpha 2-PEG, PP14 or PEP. It is synthesized by endometrial glands and no other source has been identified. Its synthesis is induced in the luteal phase of the menstrual cycle, rises to a peak in the early weeks of pregnancy and then rapidly declines as the decidua spongiosa is replaced by decidua compacta. The direction of its secretion appears to be into the amniotic fluid, and its function may be to transport a vitamin or other essential substance to the early conceptus: another possible function is immunosuppressi...Continue Reading

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Citations

Oct 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M Habiba, F al-Azzawi
May 21, 2010·Biology of Reproduction·Jae-Wook JeongFrancesco J DeMayo
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Jan 31, 2020·Biomechanics and Modeling in Mechanobiology·Tatyana KupermanDan Grisaru

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