Secretory vimentin is associated with coronary artery disease in patients and induces atherogenesis in ApoE-/- mice.

International Journal of Cardiology
Dong Huo GongLin Lu

Abstract

The present study aimed to investigate the relationship between serum levels of secretory vimentin and coronary artery disease (CAD). The biological effect of secretory vimentin was ascertained by experiments. We analysed serum levels of secretory vimentin in CAD patients (n = 288) and non-CAD controls (n = 195) by ELISA. To evaluate the pro-inflammatory effects of secreted vimentin, the human aortic endothelial cells (HAECs) and human peripheral blood mononuclear cells (PBMCs) were treated with recombinant vimentin or saline. Intraperitoneal injection of vimentin (1 μg/each) or saline was performed every other day for 12 weeks in ApoE-/- mice for assessment of atherogenic effect. Serum levels of secretory vimentin were significantly increased in CAD patients than in health controls (p < 0.05), and correlated with the number of diseased coronary arteries, Syntax and Gensini score (for all comparison, p < 0.01). Logistic regression analysis showed that vimentin level is an independent determinant of CAD. In experiments, recombinant vimentin protein enhanced the expression of adhesion molecules and inflammatory cytokines in both endothelial cells and macrophages. This protein also promoted macrophage-endothelial cells adhesion in...Continue Reading

Citations

Jul 8, 2020·International Journal of Molecular Sciences·Irene RamosDolores Pérez-Sala
May 27, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·SeoYeon KimYoung Mi Park
Feb 5, 2021·Stroke; a Journal of Cerebral Circulation·Jun XiaoGunnar Engström
Jul 13, 2021·International Journal of Cardiology·Hongfeng LiuYing Hu
Dec 7, 2021·Small·Łukasz SuprewiczAlison E Patteson
Dec 22, 2021·DNA and Cell Biology·Yamin LiangDangheng Wei

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