Secular trends (1990-2013) in serotypes and associated non-susceptibility of S. pneumoniae isolates causing invasive disease in the pre-/post-era of pneumococcal conjugate vaccines in Spanish regions without universal paediatric pneumococcal vaccination

Vaccine
A FenollL Aguilar

Abstract

This study analyzed temporal trends of non-susceptibility/serotypes in invasive pneumococci from Spanish regions where pneumococcal conjugate vaccines (PCVs) were not included in paediatric immunization programmes. All invasive pneumococcal isolates voluntarily sent to the Spanish Reference Laboratory for Pneumococci (January 1990-December 2013) from hospitals located in target study regions were analyzed by age group. The PCV estimated coverage in children <24 months was correlated with 13-valent PCV (PCV13) serotypes trends. A total of 28,124 invasive isolates were analyzed: 3138 (11.2%) from children <24 months, 2161 (7.7%) from children 24-59 months, 781 (2.8%) from children 5-14 years, and 22,044 (78.4%) from adults. The estimated coverage increased from 17.6% (2002) to around 40% (2010-2013). The percentage of PCV13 serotypes among all isolates over time followed a cubic significant trend (R(2)=0.884), with an increasing trend up to 2001 followed by a decrease (more prominent from 2010 onwards). The estimated PCVs coverage was significantly correlated with the decrease in the percentage of PCV13 isolates in children <24 months (r(2)=0.824) and in adults (r(2)=0.786), mainly due to decreases in serotypes 1 and 7F in adults...Continue Reading

References

Jan 31, 2003·The Journal of Antimicrobial Chemotherapy·A FenollJ Casal
Oct 11, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D TarragóI Obando
Jul 7, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C EstevaC Muñoz-Almagro
Feb 15, 2012·The Pediatric Infectious Disease Journal·Robert CohenEmmanuelle Varon
Feb 25, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M A FletcherG Sylvester
Mar 29, 2014·The Pediatric Infectious Disease Journal·Anita M LoughlinStephen I Pelton
Apr 22, 2014·Clinical Therapeutics·Alain GervaixGeorge A Syrogiannopoulos
Jul 19, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zitta Barrella HarboePalle Valentiner-Branth

❮ Previous
Next ❯

Citations

Jun 4, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mitsuyo KawaguchiyaNobumichi Kobayashi
Feb 24, 2016·Current Opinion in Pulmonary Medicine·Catia CillónizAntoni Torres
Jun 2, 2018·Journal of Medical Microbiology·Helena ŽemličkováMatej Medvecký
Feb 10, 2017·PloS One·Sivani JonnalagaddaDavidson H Hamer
Nov 23, 2019·Diagnostics·María Del Mar García-SuárezEnrique Santiago
Nov 10, 2018·Multidisciplinary Respiratory Medicine·María-José GiménezJuan José Granizo
Jun 5, 2017·Scientific Reports·Watcharapong MitsuwanManuel J Rodríguez-Ortega
Sep 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara de MiguelJose Yuste

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Acute Disseminated Encephalomyelitis

Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system. Discover the latest research on acute disseminated encephalomyelitis here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.