Secular Trends in the Cost of Immunosuppressants after Solid Organ Transplantation in the United States

Clinical Journal of the American Society of Nephrology : CJASN
Margaret E HelmuthAbigail R Smith

Abstract

Immunosuppressive medications are critical for maintenance of graft function in transplant recipients but can represent a substantial financial burden to patients and their insurance carriers. To determine whether availability of generic immunosuppressive medications starting in 2009 may have alleviated some of that burden, we used Medicare Part D prescription drug events between 2008 and 2013 to estimate the average annualized per-patient payments made by patients and Medicare in a large national sample of kidney, liver, and heart transplant recipients. Repeated measures linear regression was used to determine changes in payments over the study period. Medicare Part D payments for two commonly used immunosuppressive medications, tacrolimus and mycophenolic acid (including mycophenolate mofetil and mycophenolate sodium), decreased overall by 48%-67% across organs and drugs from 2008 to 2013, reflecting decreasing payments for brand and generic tacrolimus (21%-54%), and generic mycophenolate (72%-74%). Low-income subsidy payments, which are additional payments made under Medicare Part D, also decreased during the study period. Out-of-pocket payments by patients who did not receive the low-income subsidy decreased by more than th...Continue Reading

References

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Citations

Mar 2, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Cher Thomas
Mar 2, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Lisa M Potter
Nov 11, 2019·Journal of the American Society of Nephrology : JASN·Matthew KadatzScott Klarenbach
Nov 23, 2019·Pharmacogenomics·Kimberly M DeiningerChristina L Aquilante
Mar 8, 2020·Enfermedades infecciosas y microbiología clínica·Jose Tiago SilvaJosé María Aguado
Feb 11, 2021·Clinical Kidney Journal·Manon J M van OostenVianda S Stel
Apr 11, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Arpana Iyengar, M I McCulloch

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