Securigera securidaca seed medicinal herb supplementation of diets improves pulmonary hypertensive response in broiler chickens reared at high altitude

Journal of Animal Physiology and Animal Nutrition
Behnam Ahmadipour

Abstract

This experiment was conducted to evaluate the effects of dietary Securigera securidaca seed powder on growth performance, haematological parameters, cardiac indices, electrocardiographic parameters and expression of catalase (CAT), endothelin 1 (ET-1) and inducible nitric oxide synthase (iNOS) genes in the lung in the broilers reared at high altitude (2,100 m above sea level). A total number of 200-day-old male broilers (Ross 308) were randomly assigned to five treatments including different levels of S. securidaca 0, 1, 2, 3 and 4 g/kg in a 42-day trial. The results of this experiment showed that the dietary inclusion of S. securidaca powder improvement in feed conversion ratio (p < 0.05). The dietary utilization of 2-4 g/kg S. securidaca significantly increased concentrations of nitric oxide (NO), although significantly lower serum concentrations of malondialdehyde (MDA) and significantly decrease T, R, S electrocardiogram waves compared with control group. Also, the dietary inclusion of 2-4 g/kg S. securidaca prevented right ventricular hypertrophy and increased the expression of iNOS and CAT genes in lung tissue of broilers. On the other hand, S. securidaca significantly suppressed the expression of ET-1 in lung tissue. Gen...Continue Reading

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