SED1 function during mammalian sperm-egg adhesion

Current Opinion in Cell Biology
Barry D ShurCarey Rodeheffer

Abstract

A prerequisite for successful fertilization is the species-specific binding of sperm to the extracellular coat of the egg. Gamete binding triggers the release of sperm hydrolytic enzymes that digest a path through the egg coat, thus bringing sperm into proximity with the egg plasma membrane where gamete fusion occurs. Although some components of the sperm membrane and the egg coat that participate in sperm-egg interactions have been identified, results from targeted deletions and gene substitutions indicate that other, as yet unidentified, gamete receptors must contribute to sperm-egg binding. Recent studies implicate the bi-motif protein, SED1, as being required for successful sperm-egg adhesion in mouse. SED1 contains Notch-like EGF repeats as well as discoidin/F5/8 complement domains--motifs that mediate a variety of cell-cell and cell-matrix interactions. SED1's ability to promote gamete adhesion resides within its two discoidin/F5/8C domains, which are able to dock to substrates as diverse as phospholipid membranes and extracellular matrices. SED1 is also expressed in a wide range of tissues and epithelia, where it may function similarly as an adhesive protein facilitating cell-cell and/or cell-matrix interactions.

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Citations

Jul 24, 2008·The International Journal of Developmental Biology·Barry D Shur
Feb 26, 2009·Journal of Cell Science·Adam S Raymond, Barry D Shur
Nov 8, 2008·Fertility and Sterility·Susannah D CoplandBarry D Shur
Mar 13, 2016·Biochimica Et Biophysica Acta·Joanne ChiaFrederic Bard
Aug 19, 2007·Biochimica Et Biophysica Acta·A KiedzierskaJ Otlewski
Feb 11, 2009·Journal of Cellular Biochemistry·Adam RaymondBarry D Shur
Jul 28, 2011·Journal of Cellular Physiology·Brett NixonR John Aitken
Apr 28, 2010·Molecular Reproduction and Development·Adam S RaymondBarry D Shur
Jan 19, 2006·Molecular and Cellular Endocrinology·Barry D ShurAdam Raymond
Aug 20, 2016·BMC Genomics·Bing YuChuan-Xi Zhang
Nov 1, 2016·Molecular Human Reproduction·A FranchiL C Giojalas
Sep 13, 2015·Reproductive Sciences·Min Liu
Oct 4, 2016·PloS One·Olivia JerczynskiClémence Belleannée
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Jun 28, 2020·Journal of Cellular Physiology·Jun WangJungang Xie
Aug 8, 2020·Biology of Reproduction·Gagandeep Kaur Gahlay, Neha Rajput
Jul 26, 2006·Molecular Biology and Evolution·Ondrej PodlahaJianzhi Zhang

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