Sedation, Delirium, and Cognitive Function After Critical Illness

Critical Care Clinics
Timothy D Girard

Abstract

Delirium has been consistently identified as a risk factor for critical illness brain injury, but ICU patients are exposed to a multitude of risk factors for delirium and it remains unclear which of these risk factors should be targeted to improve long-term cognitive outcomes. Because exposure to sedating medications-which are frequently used to treat unwanted yet common symptoms during critical illness-is a risk factor for delirium that is directly controlled by clinicians, the relationship between sedation, delirium, and long-term cognition is of great interest to clinicians, researchers, and patients. This review describes theoretic relationships between sedation, delirium, and long-term cognition and reviews the evidence supporting these theoretic relationships.

Citations

Jul 7, 2019·Molecular Neurobiology·Jolie BarterThomas C Foster
Jun 11, 2020·Scientific Reports·Allison M ScottMike T Lin
Aug 23, 2020·International Journal of Environmental Research and Public Health·Michał P PlutaŁukasz J Krzych
Oct 14, 2020·Critical Care Medicine·Helene Korvenius NedergaardPalle Toft
Apr 21, 2021·Journal of Critical Care·Anne-Françoise Rousseau, Jean-Charles Preiser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Jukka Takala
Asian Journal of Psychiatry
Aarya Krishnan RajlakshmiSandeep Grover
© 2022 Meta ULC. All rights reserved