Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants

Neonatology
Janneke DekkerArjan Te Pas

Abstract

There is no data available whether sedation should be given during minimally invasive surfactant therapy (MIST). To compare the level of comfort of preterm infants receiving sedation versus no sedation for MIST. A retrospective study of preterm infants receiving MIST was performed in Leiden University Medical Center in 2014. Sedation (propofol 1 mg/kg) was optional and left to the discretion of the caregiver. Standardized COMFORTneo scores were compared, and COMFORTneo <14 was considered comfortable. Basic characteristics and complications were noted. In 38 infants receiving MIST, 23 received propofol and 15 were not sedated. Mean (SD) gestational age [29 (2) vs. 29 (3) weeks] and birth weight [1,312 (483) vs. 1,469 (588) g] were not different. Median (IQR) COMFORTneo was not different between the groups before [11 (9-15) vs. 10 (8-12)] and after MIST [10 (8-12) vs. 9 (8-10)], but lower in the sedated group during MIST [12 (9-17) vs. 20 (15-23)] with more often COMFORTneo <14 (56 vs. 11%). Duration of MIST [2 (2-4) vs. 3 (2-7) min] and occurrence of bradycardia (13 vs. 33%) and hypotension (21 vs. 18%) were not different. Although not significant, intubation occurred more often in the sedated group (during MIST: 9 vs. 0%, <24 h...Continue Reading

Citations

Sep 30, 2016·European Journal of Pediatrics·Vincent RigoIsabelle Broux
May 26, 2017·Neonatology·Eleanor J MolloyChristian P Speer
Jul 21, 2017·Archives of Disease in Childhood·Tim J van Hasselt
Jun 20, 2019·Pediatric Research·Janneke DekkerArjan B Te Pas
Dec 14, 2019·Pediatric Pulmonology·Anders NordValeria Perez-de-Sa
Dec 13, 2016·European Journal of Pediatrics·Daniel KlotzHans Fuchs
Sep 7, 2018·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Gustavo RochaHercília Guimarães
Dec 19, 2020·Pulmonary Pharmacology & Therapeutics·Beena G SoodXinguang Chen
Apr 11, 2019·Seminars in Fetal & Neonatal Medicine·Manon Tauzin, Xavier Durrmeyer
May 11, 2021·The Cochrane Database of Systematic Reviews·Mohamed E Abdel-LatifPeter A Dargaville
Jul 19, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Matthew LinKristen T Leeman

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