PMID: 11310459Apr 20, 2001Paper

Sedation for children requiring wound repair: a randomised controlled double blind comparison of oral midazolam and oral ketamine

Emergency Medicine Journal : EMJ
Paul Younge, J M Kendall

Abstract

To compare the efficacy of oral ketamine (10 mg/kg) with oral midazolam (0.7 mg/kg) in providing sedation for suturing of lacerations. Prospective, randomised, double blinded trial with consecutive, concealed recruitment of 59 children aged 1 to 7 with wounds requiring local anaesthetic (LA) injection or topical LA with an anxiety score greater than one. Tolerance to LA injection was better with ketamine (p=0.029) and tolerance to procedure after LA injection showed a trend towards being improved with ketamine (p=0.067). There was no difference in tolerance to LA application or procedure in children receiving topical LA. Time to reach a sedation score of less than four was faster with ketamine (medians 20 versus 43 minutes, p=0.001) but times from dosing to discharge (medians 105 and 110 minutes) were similar. Inconsolable agitation was reported with midazolam in six cases. Dysphoria was not noted with ketamine. Vomiting was more common with ketamine but not significantly so (six versus two, p = 0.14). Oxygen desaturations were noted in both groups. Ataxia after discharge was seen in four patients, two in each group. Thirty six per cent of children showed new behavioural disturbances in the two weeks after discharge, more commo...Continue Reading

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Citations

Jan 17, 2012·Pediatric Radiology·C Heng VongP Marec Bérard
Apr 27, 2004·Emergency Medicine Journal : EMJ·M C Howes
Mar 1, 2005·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Astrid C S PulleyNicholas W Lerche
Mar 27, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·G Orliaguet, UNKNOWN groupe d’experts Sfar-SFMU
Mar 31, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·G Orliaguet, UNKNOWN groupe d’experts Sfar-SFMU
Nov 3, 2007·The Journal of Emergency Medicine·Christopher S WeaverWilliam H Cordell
Apr 3, 2007·Emergency Medicine Clinics of North America·Chad S CrystalBenjamin Harrison
Apr 15, 2005·Paediatric Anaesthesia·Elaine Christiansen, Neil Chambers
Oct 7, 2005·Pharmacotherapy·Rakhee B Mistry, Milap C Nahata
Jan 28, 2015·Journal of Pain & Palliative Care Pharmacotherapy·Danielle M Noreika, Patrick Coyne
Nov 9, 2016·Annals of Emergency Medicine·Daniel S TszePeter S Dayan
Dec 6, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Charles Schleien, Ariel Brandwein
Aug 20, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Marie Christy Sharafine StephenGeorge Ani Mathew
May 21, 2016·The Cochrane Database of Systematic Reviews·Aaron ConwayJoanna R Sutherland
May 4, 2018·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jamie L MillerPeter N Johnson
Mar 2, 2021·Frontiers in Pediatrics·Sonja FontanaJulia Elrod

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