Sedation Protocol During Bevacizumab Intravitreal Injection in Preterm Infants With Retinopathy of Prematurity

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
Jamie L MillerR Michael Siatkowski

Abstract

This study describes outcomes of intravenous (IV) analgesics and sedatives for bedside intravitreal bevacizumab injections for retinopathy of prematurity. This retrospective study included infants receiving intravitreal bevacizumab injections between January 2012 and May 2016. Infants were excluded if bevacizumab was administered under general anesthesia or for incomplete records. Data collection included demographics, sedation and analgesia regimen, and cardiopulmonary adverse events (AEs). The primary objective was to identify the median doses of the IV analgesics and sedatives. The secondary objectives included the number of patients with cardiopulmonary AEs and those with procedure success, defined as procedure completion without interruption and absence of interventions. Fifteen infants were included. Fourteen (93.3%) were initiated on a fentanyl infusion at a median of 2 mcg/kg/hr (IQR, 2-3.6), and 12 (80%) received midazolam infusions at a median of 0.06 mg/kg/hr. All patients received at least 1 IV neuromuscular blocker dose just prior to the procedure. Only 2 patients (13.3%) required an increase in their fentanyl or midazolam infusions. Procedure success was achieved in 13 patients (86.7%). Five patients (33.3%) exper...Continue Reading

References

Jul 27, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·J SpectorF Bednarek
Nov 26, 2010·Retina·Gregory R BlahaJeffrey L Marx
Feb 18, 2011·The New England Journal of Medicine·Helen A Mintz-HittnerUNKNOWN BEAT-ROP Cooperative Group
May 24, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maria Ana Martínez CastellanosHugo Quiroz-Mercado
Apr 9, 2013·European Journal of Ophthalmology·Mehmet Ali SekerogluUmut Arslan
Apr 22, 2015·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Maram IsaacNasrin Tehrani
Mar 25, 2016·Acta Ophthalmologica·Reza KarkhanehHamidreza Torabi

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