PMID: 9543377Apr 16, 1998Paper

Sedation with intravenous benzodiazepine and ketamine for renal biopsies

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
M RiavisM G Bianchetti

Abstract

"Lytic cocktail" is the customary sedation before percutaneous renal biopsy. Owing to deficient sedation and respiratory depression, this approach is no longer advised. The intravenous combination of a benzodiazepine plus ketamine, which has been found to be effective and safe in several conditions, was therefore used for 60 pediatric biopsies. In addition to pulse oximetry, a physician trained in airway management monitored the patient. The quality of sedation was acceptable (n = 7) or optimal (n = 53) in all cases. None of the patients required ventilation or intubation. A mild oxygen desaturation lasting 4 min or less was detected in 6 patients. None of the patients experienced major change in respiratory rate or blood pressure. The administration of ketamine and, in some cases, the biopsy puncture were associated with a mildly increased heart rate. In conclusion, a benzodiazepine plus ketamine provides effective deep sedation for renal biopsy in childhood.

Citations

Apr 23, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·D K L CheukG C F Chan
Apr 15, 1999·Current Opinion in Pediatrics·R W Chesney
Nov 25, 2003·Regional Anesthesia and Pain Medicine·Isabelle MuratBarbara Tourniaire
Jul 24, 2004·Seminars in Pediatric Surgery·Michael S Mazurek
May 9, 2006·Paediatric Anaesthesia·Grzegorz J Bujok, Hanna Misio ek

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