Sedative and Analgesic Pharmacokinetics During Pediatric ECMO.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
Kanecia O ZimmermanKevin M Watt

Abstract

Sedatives and analgesics are often administered to critically ill children supported by extracorporeal membrane oxygenation (ECMO) to facilitate comfort and to decrease risks of life-threatening complications. Optimization of sedative and analgesic dosing is necessary to achieve desired therapeutic benefits and must consider interactions between the circuit and patient that may affect drug metabolism, clearance, and impact on target organs. This paper reviews existing in vitro and pediatric in vivo literature concerning the effects of the ECMO circuit on sedative and analgesic disposition and offers dosing guidance for the management of critically ill children receiving these drugs.

References

Jun 1, 1990·Journal of Cardiothoracic Anesthesia·D A RosenD L Silvasi
Jan 1, 1990·European Journal of Clinical Pharmacology·E Jacqz-AigrainI Robieux
Mar 1, 1990·British Journal of Clinical Pharmacology·J HasselströmJ Säwe
Jul 1, 1990·The Journal of Perinatal & Neonatal Nursing·E Caron, D P Maguire
Nov 1, 1981·Canadian Anaesthetists' Society Journal·J G RevesL R Smith
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·C BondL Yu
Mar 4, 2000·Cellular and Molecular Neurobiology·N J Abbott
Jun 28, 2002·The Annals of Pharmacotherapy·Eugene NgAnna Taddio
Aug 28, 2002·The Annals of Pharmacotherapy·Tep M Kang
Feb 1, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hussain MullaDavid R Upton
Feb 28, 2003·The Annals of Thoracic Surgery·Jerrold H Levy, Kenichi A Tanaka
Aug 26, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D ProjeanJ Ducharme
Sep 19, 2003·The New England Journal of Medicine·Gregory L KearnsRalph E Kauffman
Jan 29, 2005·Intensive Care Medicine·Jeroen W B PetersDick Tibboel
Feb 8, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shirley Hui-StickleStuart L Goldstein
Apr 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Way Seah LeeDeirdre Anne Kelly
May 24, 2005·Journal of Pain and Symptom Management·Jörn Lötsch
Dec 21, 2005·Perfusion·Varsha Bhatt-Meht, Gail Annich
May 16, 2006·Intensive Care Medicine·Stephen PlayforUNKNOWN Analgesia and Neuromuscular Blockade Working Group
Jun 29, 2006·Clinical Pharmacokinetics·Jeroen W B PetersDick Tibboel
Mar 31, 2009·Journal of Critical Care·Leslie W HayesAshita J Tolwani
Apr 22, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Andrew H SmithMary B Taylor
Nov 11, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·R Britt McILwainAkhil Maheshwari
Sep 24, 2010·Intensive Care Medicine·E D WildschutD Tibboel
Nov 9, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nienke J VetSaskia N de Wildt
Apr 6, 2011·Journal of Intensive Care Medicine·Daniel A Diedrich, Daniel R Brown
Apr 19, 2011·Journal of Pediatric Surgery·Samir K GadepalliGeorge B Mychaliska
Apr 14, 2012·Clinical Journal of the American Society of Nephrology : CJASN·David J AskenaziGeoffrey M Fleming
May 24, 2012·Journal of Opioid Management·Pamela D ReiterEmily L Dobyns
Sep 4, 2012·Journal of Opioid Management·Senthilkumar SadhasivamAlexander A Vinks
Oct 17, 2012·Critical Care : the Official Journal of the Critical Care Forum·Kiran ShekarJohn F Fraser

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