PMID: 6405420Jan 1, 1983Paper

Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): relationship to inhibition of brain adenosine deaminase

Psychopharmacology
W B MendelsonP Skolnick

Abstract

Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-dependent manner. Nonetheless, a marked reduction in electroencephalographically defined sleep was observed in rats during a period when both spontaneous motor activity and ADA activity were profoundly inhibited. These data suggest that EHNA produces in rats a state of 'quiescent waking', which may be related to the observed inhibition of brain ADA activity.

References

Jul 1, 1978·Journal of Studies on Alcohol·W B MendelsonR J Wyatt
Oct 1, 1976·Life Sciences·J W Phillis, J P Edstrom
Oct 15, 1974·Biochemical Pharmacology·M MaitreP Mandel
Jul 1, 1974·Pharmacology, Biochemistry, and Behavior·W B MendelsonR J Wyatt
Oct 1, 1974·The Biochemical Journal·I Pull, H McIlwain
Jan 1, 1973·Revue Roumaine De Physiologie = Romanian Journal of Physiology·I HaulicăA Busuioc
Oct 1, 1973·Journal of Neurochemistry·I HaulicăF Topoliceanu
Sep 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·U Schwabe, T Trost
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R F BrunsS H Snyder
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M Williams, E A Risley
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S H SnyderJ W Daly
Mar 1, 1982·Journal of Medicinal Chemistry·J W Daly

❮ Previous
Next ❯

Citations

Jun 1, 1984·European Journal of Pharmacology·J W Phillis, R E Delong
Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·J W PhillisD O Washington
Nov 1, 1989·Pharmacology, Biochemistry, and Behavior·J V MartinW B Mendelson
Jan 1, 1988·Neurochemistry International·A L Gundlach, G A Johnston
Apr 11, 1983·Neuroscience Letters·J N CrawleyP J Marangos
Jan 4, 1993·Neuroscience Letters·S M DelaneyJ D Geiger
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L O Trussell, M B Jackson
Jan 1, 1991·Journal of Neurochemistry·M OrfordD Saggerson
Jan 27, 2004·The Journal of Pharmacology and Experimental Therapeutics·Linda Yip, Yin Nam Kwok

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.