Abstract
The sedative effects of intramuscular (IM) alfaxalone in 2-hydroxypropyl-beta-cyclodextrin (alfaxalone-HPCD) were evaluated in cats. The cats were treated with alfaxalone-HPCD in five occasions with a minimum 14-day interval between treatments: an IM injection of 1.0 mg/kg (IM1), 2.5 mg/kg (IM2.5), 5 mg/kg (IM5) or 10 mg/kg (IM10), or an intravenous injection of 5 mg/kg (IV5). The sedative effects were evaluated subjectively using a composite measurement scoring system (a maximum score of 16). Cardio-respiratory variables were measured non-invasively. The median sedation scores peaked at 10 min (score 9), 15 min (score 14), 10 min (score 16), 10 to 20 min (score 16) and 2 to 5 min (score 16) after the IM1, IM2.5, IM5, IM10 and IV5 treatments, respectively. The IM5 treatment produced longer lasting sedation, compared to the IV5 treatment. Durations of maintenance of lateral recumbency after the IM10 treatment (115 ± 22 min) were longer than those after the IM2.5 (40 ± 15 min), IM5 (76 ± 21 min) and IV5 treatments (50 ± 5 min). Cardio-respiratory variables remained within clinically acceptable ranges, except for each one cat that showed hypotension (<60 mmHg) after the IM10 and IV5 treatments. Tremors, ataxia and opisthotonus-lik...Continue Reading
References
Sep 1, 1992·Anesthesiology·T E AlbertsonR M Joy
Jan 1, 1971·British Journal of Anaesthesia·K J ChildD J Twissell
Nov 22, 1980·The Veterinary Record·N H Dodman
Sep 1, 1996·The British Veterinary Journal·L K Cullen
Apr 8, 1999·Clinical Techniques in Small Animal Practice·A Z Karas
Sep 11, 1999·Zentralblatt für Veterinärmedizin. Reihe A·T MutohH Tsubone
Dec 1, 2000·Pain·C S GoodchildR Nadeson
Feb 17, 2001·Journal of Applied Toxicology : JAT·K H DiehlUNKNOWN European Federation of Pharmaceutical Industries Association and European Centre for the Validation of Alternative Methods
Mar 30, 2001·American Journal of Veterinary Research·T MutohN Sasaki
Sep 10, 2002·Journal of the American Veterinary Medical Association·Karen M PedersenHenrik D Pedersen
Jan 14, 2003·Journal of the American Veterinary Medical Association·André L SelmiGlenda R Barbudo-Selmi
Nov 13, 2003·Progress in Neurobiology·Jeremy J LambertJohn A Peters
Sep 4, 2004·Journal of the American Veterinary Medical Association·Alison A SmithRobin D Gleed
Jan 3, 2007·Journal of Feline Medicine and Surgery·Ashley J Wiese, William W Muir
Sep 17, 2008·Veterinary Anaesthesia and Analgesia·William MuirTed Whittem
Nov 5, 2008·American Journal of Veterinary Research·Barbara AmbrosKirby S Pasloske
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·T WhittemM G Ranasinghe
Jan 6, 2009·Veterinary Anaesthesia and Analgesia·William MuirTed Whittem
Feb 28, 2009·Australian Veterinary Journal·S ZakiY Miyaki
Mar 17, 2010·The Veterinary Record·P J MurisonF M Taboada
Jul 21, 2010·The Veterinary Record·F Martinez Taboada, P J Murison
Apr 26, 2011·Journal of Feline Medicine and Surgery·Ilona RodanUNKNOWN American Animal Hospital Association
Nov 29, 2011·Veterinary Anaesthesia and Analgesia·Carolina P JiménezHatim Alibhai
Mar 15, 2012·Veterinary Anaesthesia and Analgesia·Joanne N MichouJacqueline C Brearley
Apr 11, 2012·Veterinary Anaesthesia and Analgesia·Alessandra MathisHatim I K Alibhai
Feb 16, 2013·Journal of Feline Medicine and Surgery·Tamara L GrubbTania E Perez
Aug 24, 2013·Veterinary Anaesthesia and Analgesia·Salma FerchichiJérôme R E del Castillo
Citations
Jul 13, 2016·Journal of Feline Medicine and Surgery·Latifa KhenissiGwenola Touzot-Jourde
Mar 23, 2018·New Zealand Veterinary Journal·D Rodrigo-MocholíP Marín
Dec 2, 2017·Journal of Feline Medicine and Surgery·Jeannette Cremer, Carolina H Riccó
Sep 28, 2017·Journal of Feline Medicine and Surgery·Marcella C GranfoneLesley J Smith
Dec 23, 2017·The Journal of Veterinary Medical Science·Sayed Fathi El-HawariKazuto Yamashita
Jul 13, 2020·Journal of Medical Primatology·Takako Miyabe-NishiwakiKatsuki Nakamura
Nov 8, 2019·Journal of Feline Medicine and Surgery·Kira Lm MoserDaniel Sj Pang
May 29, 2020·The Journal of Veterinary Medical Science·Sou WadaKazuto Yamashita
Jul 7, 2017·Journal of Feline Medicine and Surgery·Tatum ArmstrongDaniel Sj Pang
Jun 1, 2019·Journal of the American Veterinary Medical Association·Julie A BalkoSathya K Chinnadurai
May 8, 2019·The Journal of Veterinary Medical Science·Yushun IshikawaKazuto Yamashita
Jan 13, 2021·The Journal of Veterinary Medical Science·Jun TamuraKazuto Yamashita
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Rachel C HectorLisa L Wolfe
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Matthew C MillowayJulie A Balko
Oct 27, 2020·Journal of Feline Medicine and Surgery·Bradley T Simon, Paulo V Steagall
Jan 17, 2021·Veterinary Anaesthesia and Analgesia·Avishag TuvalYael Shilo-Benjamini
Jan 27, 2020·Journal of Neuroscience Methods·Alexandra T LevineBlake E Butler
Mar 4, 2021·Journal of Feline Medicine and Surgery·Emily P WheelerLois A Wetmore
Aug 15, 2020·Veterinary Anaesthesia and Analgesia·Eleonora LazzariniAlessandra M Carotenuto
Jun 22, 2021·Frontiers in Veterinary Science·Cyrielle FinckGuy Beauchamp
Jul 29, 2021·Veterinary Anaesthesia and Analgesia·Patricia E KunzeCarlos R Sanchez
Jul 8, 2017·Veterinary Anaesthesia and Analgesia·Julia DeutschElizabeth A Leece