Sedative effects of intramuscular alfaxalone administered to cats

The Journal of Veterinary Medical Science
Jun TamuraKazuto Yamashita

Abstract

The sedative effects of intramuscular (IM) alfaxalone in 2-hydroxypropyl-beta-cyclodextrin (alfaxalone-HPCD) were evaluated in cats. The cats were treated with alfaxalone-HPCD in five occasions with a minimum 14-day interval between treatments: an IM injection of 1.0 mg/kg (IM1), 2.5 mg/kg (IM2.5), 5 mg/kg (IM5) or 10 mg/kg (IM10), or an intravenous injection of 5 mg/kg (IV5). The sedative effects were evaluated subjectively using a composite measurement scoring system (a maximum score of 16). Cardio-respiratory variables were measured non-invasively. The median sedation scores peaked at 10 min (score 9), 15 min (score 14), 10 min (score 16), 10 to 20 min (score 16) and 2 to 5 min (score 16) after the IM1, IM2.5, IM5, IM10 and IV5 treatments, respectively. The IM5 treatment produced longer lasting sedation, compared to the IV5 treatment. Durations of maintenance of lateral recumbency after the IM10 treatment (115 ± 22 min) were longer than those after the IM2.5 (40 ± 15 min), IM5 (76 ± 21 min) and IV5 treatments (50 ± 5 min). Cardio-respiratory variables remained within clinically acceptable ranges, except for each one cat that showed hypotension (<60 mmHg) after the IM10 and IV5 treatments. Tremors, ataxia and opisthotonus-lik...Continue Reading

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Citations

Jul 13, 2016·Journal of Feline Medicine and Surgery·Latifa KhenissiGwenola Touzot-Jourde
Mar 23, 2018·New Zealand Veterinary Journal·D Rodrigo-MocholíP Marín
Sep 28, 2017·Journal of Feline Medicine and Surgery·Marcella C GranfoneLesley J Smith
May 8, 2019·The Journal of Veterinary Medical Science·Yushun IshikawaKazuto Yamashita
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Rachel C HectorLisa L Wolfe
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Matthew C MillowayJulie A Balko
Oct 27, 2020·Journal of Feline Medicine and Surgery·Bradley T Simon, Paulo V Steagall
Jan 17, 2021·Veterinary Anaesthesia and Analgesia·Avishag TuvalYael Shilo-Benjamini
Mar 4, 2021·Journal of Feline Medicine and Surgery·Emily P WheelerLois A Wetmore
Aug 15, 2020·Veterinary Anaesthesia and Analgesia·Eleonora LazzariniAlessandra M Carotenuto
Jul 8, 2017·Veterinary Anaesthesia and Analgesia·Julia DeutschElizabeth A Leece

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