Sedative-hypnotic anomalies related to dose of pentobarbital in long-sleep and short-sleep selectively-bred mice

Pharmacology, Biochemistry, and Behavior
H P Alpern, T D McIntyre

Abstract

Hypnotic effects following administration of three doses of pentobarbital were evaluated in mice selectively-bred for differential hypnotic sensitivity to ethanol. Although the ethanol-sensitive Long-Sleep (LS) line displays greater sedation to a wide variety of CNS depressants (alcohols, barbiturates, benzodiazepines, general anesthetics), when compared to the ethanol-insensitive Short-Sleep (SS) line, the response pattern to pentobarbital remains equivocal. Thus, to clarify the effect of pentobarbital, certain variables (dose, sex, circadian rhythmicity) believed to be important in the expression of sleep time were evaluated. For all doses examined "sex" and "time of day tested" impacted on sleep time. With these provisos, 40 mg/kg consistently induced shorter sleep time in SS mice. The 60 mg/kg dose either failed to distinguish these two lines, or induced greater sleep times in the SS mice. The 80 mg/kg dose tended to have the same effect as the 60 mg/kg dose, but to a greater degree. Overall, it appears that for each line the dose response curve for pentobarbital is sigmoidal, but that the slope of the curve for the middle range of doses is greater for the SS line. Since pentobarbital has a unique effect on these lines of m...Continue Reading

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Citations

Sep 15, 1989·Experientia·T J PhillipsJ C Crabbe
Nov 1, 1986·Pharmacology, Biochemistry, and Behavior·T D McIntyre, H P Alpern
Jan 1, 1987·Pharmacology, Biochemistry, and Behavior·T D McIntyre, H P Alpern
Jun 1, 1995·Pharmacology, Biochemistry, and Behavior·K M MizingaM G Kolta
May 1, 1989·Brain Research Bulletin·T D McIntyre, H P Alpern
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Feb 12, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Kathryn Lemery-ChalfantCarlos Valiente

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