PMID: 8598503Jan 1, 1996Paper

Sedative-hypnotic drugs and the risk of hip fracture

Journal of Clinical Epidemiology
D K WysowskiT Hammerstrom

Abstract

A retrospective cohort study was conducted in individuals 65 years of age and older using Medicaid-reimbursed claims to assess the risk of hip fracture in users of two sedative-hypnotic drugs, triazolam and temazepam. Using the triazolam cohort as the referent group, the rate ratio was 0.92 (95% confidence interval, 0.72 to 1.17) for hip fracture with temazepam. Stratifying by age, sex, race, residence, time enrolled in Medicaid, prescription number, combinations of these, and several other potential confounding variables did not materially change the results. Compared with the short-acting benzodiazepine hypnotic temazepam, use of triazolam, an ultra-short-acting benzodiazepine hypnotic, did not decrease the risk of hip fracture. This study did not determine that either drug, compared with no use in an insomniac control group, increases the risk of hip fracture. However, because sedative-hypnotic drugs have been found in other studies to increase the risk of falling and hip fracture, they should be used with caution, especially in the elderly.

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Citations

Jan 26, 2005·Journal of the American Geriatrics Society·Oscar L LopezSteven T DeKosky
Mar 27, 2001·BMJ : British Medical Journal·C PierfitteN Moore
Oct 3, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·J EllulS Lovestone
Feb 11, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·O L LopezS T Dekosky
Aug 19, 2003·CNS Drugs·Robert G Cumming, David G Le Couteur
Nov 9, 2004·Archives of Gerontology and Geriatrics·Ragnar Asplund
Jul 13, 2006·Current Medical Research and Opinion·Larry Culpepper
Sep 13, 2000·Journal of the American Geriatrics Society·D BlazerJ T Hanlon
Aug 2, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Chia-Ming ChangKeh-Ming Lin
Feb 25, 2005·Journal of Psychopharmacology·Chris Alford, Joris Verster
Jan 27, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Bahi TakkoucheMahyar Etminan
Sep 21, 2018·Psychopharmacology·Sheng-Yun ChengChian-Jue Kuo
Oct 30, 1998·Postgraduate Medicine·D Goddard, M Kleerekoper

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