Sedentary Time and White Matter Hyperintensity Volume in Older Adults

Medicine and Science in Sports and Exercise
Ulf G BronasMelissa Lamar

Abstract

Cerebrovascular disease in the form of white matter hyperintensities (WMH) increases with age and is associated separately with sedentary time and reduced kidney function. A better understanding of the relationships among these variables would help clarify whether sedentary time should be considered more closely in older adults at particular levels of kidney function to reduce the risk of WMH. We analyzed information from 94 healthy community-dwelling older adults to determine the association of sedentary time and WMH in nondemented, nondepressed older adults, and whether level of kidney function was an effect modifier of the relationship between sedentary time and WMH. Sedentary behavior was measured using the Sedentary Behavior Questionnaire. White matter hyperintensity was assessed using whole-brain 3T magnetic resonance imaging T1- and T2-weighted images. Kidney function was calculated by the epi-chronic kidney disease formula for estimated glomerular filtration rate (eGFR). Exposures or predictors were sedentary time, age, sex, education in years, Framingham stroke risk 10-yr prediction score, and eGFR. The analytical approach was multiple linear regression. Adjusting for age, sex, education in years, Framingham stroke ris...Continue Reading

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Citations

Feb 7, 2020·Aging Clinical and Experimental Research·O OlanrewajuL Smith
Dec 22, 2020·Journal of Magnetic Resonance Imaging : JMRI·Luca MelazziniMarina Codari
Nov 17, 2020·Frontiers in Aging Neuroscience·Elizabeth A BootsMelissa Lamar
Apr 16, 2021·Ethnicity & Health·Guilherme M BalbimDavid X Marquez
Apr 20, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carlijn M MaasakkersCéline De Looze
Jun 3, 2021·International Journal of Environmental Research and Public Health·Linda D RuizMelissa Lamar

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