Sediment genotoxicity in the Tietê River (São Paulo, Brazil): in vitro comet assay versus in situ micronucleus assay studies

Ecotoxicology and Environmental Safety
Paula Suares RochaHenner Hollert

Abstract

The in vitro comet assay with the permanent fish cell line RTL-W1 and the in situ micronucleus assay using erythrocytes from indigenous tilapia (Oreochromis niloticus) were used to detect genotoxicity in Tietê River sediments (São Paulo, Brazil). Either test was successful in identifying site-specific differences in genotoxicity, with a high correlation between in situ and in vitro results indicating the relevance of the latter even for environmental studies. Discharges from São Paulo city have major impact on genotoxic effects by sediment-bound contaminants; however, overall genotoxicity decreases downstream. The high genotoxic burden of the Tietê River warrants measures to reduce the input of toxic effluents.

References

May 1, 1990·The Science of the Total Environment·C D MetcalfeB P Dunn
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
May 19, 1998·Environmental and Molecular Mutagenesis·N Titenko-HollandA J Wyrobek
Oct 26, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M A LeitãoI A Degterev
Jul 13, 2002·Archives of Environmental Contamination and Toxicology·K HilscherovaJ P Giesy
Dec 2, 2004·Mutation Research·Guosheng Chen, Paul A White
Feb 28, 2006·Ecotoxicology and Environmental Safety·Clarice Torres de LemosBernardo Erdtmann
Mar 15, 2006·Brazilian Journal of Biology = Revista Brasleira De Biologia·S RodgherM H S Rodrigues

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Citations

Oct 22, 2013·Ecotoxicology and Environmental Safety·Cristiane F FuzinattoWilliam G Matias
Jan 29, 2014·Environmental Science and Pollution Research International·João CarrolaEduardo Rocha
Mar 7, 2014·Environmental Science and Pollution Research International·Florane Le BihanicJérôme Cachot
Aug 26, 2014·Environmental Science and Pollution Research International·Bárbara Cassu ManzanoMaria Aparecida Marin-Morales
Feb 20, 2016·Bulletin of Environmental Contamination and Toxicology·Isac Silva de JesusPaulo Roberto Antunes de Mello Affonso
Jan 28, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Aude KienzlerSylvie Bony
Oct 12, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Maja ŠrutGöran I V Klobučar
Nov 15, 2014·Environmental Science and Pollution Research International·Thomas BraunbeckRuben Strecker
Oct 28, 2015·Journal of Toxicology and Environmental Health. Part a·Edimar Olegário de Campos JúniorSandra Morelli
Apr 25, 2015·Environmental Science and Pollution Research International·Paula Suares-RochaMaria Aparecida Marin-Morales
Apr 11, 2015·Environmental Science and Pollution Research International·Krisztina VinczeRita Triebskorn
Nov 5, 2014·Environmental Science and Pollution Research International·Bingli LeiJiamo Fu
Jan 16, 2010·Ecotoxicology and Environmental Safety·Paula Suares RochaThomas Braunbeck
Dec 7, 2017·Environmental Science and Pollution Research International·Amirhossein MalakahmadTaimur Khan
Apr 15, 2020·Environmental Science and Pollution Research International·Yenny RisjaniChristophe Minier
May 30, 2019·Journal of Toxicology and Environmental Health. Part a·Carine De Mendonça FranciscoBoscolli Barbosa Pereira
Jul 1, 2019·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Bojana Žegura, Metka Filipič
May 6, 2019·The Science of the Total Environment·Fisnik H AsllaniAvdulla J Alija

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