Sedimentation characteristics of leucocytes can predict bacteraemia in critical care patients

Journal of Clinical Pathology
L BogarP Tarsoly

Abstract

Early detection of blood stream infection can be lifesaving, but the results of blood cultures are not usually available before 24 hours after blood sampling. An earlier indication would lead to the initiation of immediate and adequate antibiotic treatment with obvious advantages for the patient. To evaluate the ability of leucocyte count, serum procalcitonin (PCT) concentration, erythrocyte sedimentation rate (ESR), and leucocyte antisedimentation rate (LAR) in predicting the blood culture results in critical care patients. 39 consecutive patients with their first febrile episode were investigated prospectively. LAR was determined as the percentage of leucocytes crossing the midline of a blood column upward during one hour of gravity sedimentation. The relevance of the different variables was estimated by likelihood ratio tests and area under receiver operating characteristic curves (AUC). 23 patients had positive blood culture results and 16 negative. LAR was significantly higher in bacteraemic patients than in non-bacteraemic patients (p = 0.001), but leucocyte count, ESR and PCT level failed to show significant differences. Leucocyte count, PCT, and ESR yielded low discriminative values with the AUCs of 0.66, 0.64, and 0.52...Continue Reading

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Citations

Jun 3, 2009·Critical Care Medicine·John C MarshallUNKNOWN International Sepsis Forum
Oct 5, 2012·Clinical Microbiology Reviews·Konrad ReinhartChristiane S Hartog
Jul 25, 2006·Critical Care : the Official Journal of the Critical Care Forum·Lajos BogarSandor Marton
Apr 29, 2014·BioMed Research International·George E NelsonAmita Gupta
Oct 18, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P J van der GeestA B J Groeneveld
Jul 1, 2014·Journal of Pediatric Orthopedics·Nicole I Montgomery, Scott Rosenfeld
Jun 17, 2020·Clinical Hemorheology and Microcirculation·Csaba LoiblCsaba Csontos
Oct 29, 2008·Journal of Clinical Pathology·T MolnarZ Illes
Jun 4, 2019·Clinical Hemorheology and Microcirculation·Erzsebet EzerTihamer Molnar
Feb 23, 2021·Biology of the Cell·Nicolas Garcia-SeydaOlivier Theodoly

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