Seeding Stress Resilience through Inoculation

Neural Plasticity
Archana AshokanRupshi Mitra

Abstract

Stress is a generalized set of physiological and psychological responses observed when an organism is placed under challenging circumstances. The stress response allows organisms to reattain the equilibrium in face of perturbations. Unfortunately, chronic and/or traumatic exposure to stress frequently overwhelms coping ability of an individual. This is manifested as symptoms affecting emotions and cognition in stress-related mental disorders. Thus environmental interventions that promote resilience in face of stress have much clinical relevance. Focus of the bulk of relevant neurobiological research at present remains on negative aspects of health and psychological outcomes of stress exposure. Yet exposure to the stress itself can promote resilience to subsequent stressful episodes later in the life. This is especially true if the prior stress occurs early in life, is mild in its magnitude, and is controllable by the individual. This articulation has been referred to as "stress inoculation," reminiscent of resilience to the pathology generated through vaccination by attenuated pathogen itself. Using experimental evidence from animal models, this review explores relationship between nature of the "inoculum" stress and subsequent...Continue Reading

References

May 1, 1994·Trends in Neurosciences·M DavisM Cassell
Feb 1, 1997·Trends in Neurosciences·J P Herman, W E Cullinan
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Aug 21, 2002·Stress : the International Journal on the Biology of Stress·Victoria Luine
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shoki OkudaJames L McGaugh
Sep 8, 2004·Archives of General Psychiatry·Karen J ParkerDavid M Lyons
Dec 16, 2004·Behavioral Neuroscience·Ajai Vyas, Sumantra Chattarji
Apr 12, 2005·Biological Psychiatry·Karen J ParkerDavid M Lyons
Jun 16, 2005·Neuroscience Letters·Rupshi MitraSumantra Chattarji
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rupshi MitraSumantra Chattarji
Sep 6, 2005·Psychoneuroendocrinology·Eero Kajantie, David I W Phillips
Apr 5, 2007·Nature Protocols·Alicia A Walf, Cheryl A Frye
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deveroux Ferguson, Robert Sapolsky
Aug 28, 2007·Journal of Traumatic Stress·David M Lyons, Karen J Parker
Feb 27, 2008·Neuromolecular Medicine·Benjamin N Greenwood, Monika Fleshner
Mar 3, 2009·Physiology & Behavior·Kathryn N ShepardMark E Wilson
Mar 10, 2009·Physiology & Behavior·Kathleen S Curtis, Eric G Krause
Mar 12, 2009·Physiology & Behavior·Gert J Ter HorstYanhua Lin
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Apr 13, 2010·Brain Research·Rupshi Mitra, Robert M Sapolsky
Jul 29, 2010·Expert Opinion on Biological Therapy·Rupshi Mitra, Robert M Sapolsky
Aug 17, 2010·Annual Review of Medicine·Bruce S McEwen, Peter J Gianaros
Oct 5, 2010·Learning & Memory·Basira SalehiCarmen Sandi
Oct 20, 2010·Developmental Psychobiology·David M LyonsAlan F Schatzberg
Jul 28, 2011·Stress : the International Journal on the Biology of Stress·Monika FleshnerMurray A Raskind
Nov 15, 2011·Trends in Cognitive Sciences·Ilia N Karatsoreos, Bruce S McEwen
Dec 1, 2011·Nature Reviews. Neuroscience·Maurizio PopoliGerard Sanacora
Jan 1, 2011·Biology of Mood & Anxiety Disorders·Catherine Belzung, Maël Lemoine
Sep 27, 2012·Metabolism: Clinical and Experimental·Bruce S McEwen, Linn Getz
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Bruce S McEwen

❮ Previous
Next ❯

Citations

Jul 14, 2017·Stress and Health : Journal of the International Society for the Investigation of Stress·Monica LeppmaErin C McCanlies
Aug 14, 2019·Development and Psychopathology·Elizabeth J Kirkham, Liat Levita
Jun 25, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·William BushellPaul J Mills
Jul 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Prabahan ChakrabortySumantra Chattarji
Feb 8, 2021·Neuroscience and Biobehavioral Reviews·Terence Y PangRupshi Mitra
Mar 27, 2020·Trends in Neurosciences·Sahana Murthy, Elizabeth Gould

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Related Papers

Neurobiology of Stress
Nicole M EnmanElisabeth J Van Bockstaele
Psychosomatic Medicine
Victoria E BurnsMark Drayson
Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
Jennifer M Knight
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Israel Liberzon, Dayan Knox
© 2022 Meta ULC. All rights reserved