Abstract
To introduce an experimental approach for direct comparison of the primate optic nerve head (ONH) before and after death by exsanguination. The ONHs of four eyes from three monkeys were imaged with spectral-domain optical coherence tomography (OCT) before and after exsanguination under controlled IOP. ONH structures, including the Bruch membrane (BM), BM opening, inner limiting membrane (ILM), and anterior lamina cribrosa (ALC) were delineated on 18 virtual radial sections per OCT scan. Thirteen parameters were analyzed: scleral canal at BM opening (area, planarity, and aspect ratio), ILM depth, BM depth; ALC (depth, shape index, and curvedness), and ALC visibility (globally, superior, inferior, nasal, and temporal quadrants). All four ALC quadrants had a statistically significant improvement in visibility after exsanguination (overall P < 0.001). ALC visibility increased by 35% globally and by 36%, 37%, 14%, and 4% in the superior, inferior, nasal, and temporal quadrants, respectively. ALC increased 4.1%, 1.9%, and 0.1% in curvedness, shape index, and depth, respectively. Scleral canals increased 7.2%, 25.2%, and 1.1% in area, planarity, and aspect ratio, respectively. ILM and BM depths averaged -7.5% and -55.2% decreases in d...Continue Reading
References
Jan 1, 1981·Archives of Ophthalmology·H A Quigley, E M Addicks
Feb 1, 1994·The British Journal of Ophthalmology·J B Jonas, M C Fernández
Feb 24, 2000·The British Journal of Ophthalmology·J AlbonD L Easty
May 31, 2001·Ophthalmology·J B JonasJ K Hayler
Nov 24, 2004·Progress in Retinal and Eye Research·Claude F BurgoyneRichard T Hart
Jan 27, 2009·Investigative Ophthalmology & Visual Science·Ian A Sigal
Feb 17, 2009·Experimental Eye Research·Ian A Sigal, C Ross Ethier
Jul 25, 2009·Investigative Ophthalmology & Visual Science·Hongli YangClaude F Burgoyne
Sep 24, 2009·Experimental Eye Research·Ian A SigalC Ross Ethier
Jul 16, 2010·Biomechanics and Modeling in Mechanobiology·Rafael GrytzJost B Jonas
Oct 1, 2010·Investigative Ophthalmology & Visual Science·Ian A SigalJ Crawford Downs
Jan 11, 2011·Investigative Ophthalmology & Visual Science·Nicholas G StrouthidisClaude F Burgoyne
May 10, 2011·Investigative Ophthalmology & Visual Science·Michaël J A GirardJean Martial Mari
Jul 1, 2011·Investigative Ophthalmology & Visual Science·Hongli YangClaude F Burgoyne
Jan 10, 2012·The British Journal of Ophthalmology·Mari HiraokaMasahiko Takada
Sep 8, 2012·Investigative Ophthalmology & Visual Science·Ian A SigalRichard Bilonick
Jun 14, 2013·Journal of Glaucoma·Sung Chul Park
Jul 13, 2013·Biomedical Optics Express·Nripun SredarJason Porter
Jul 26, 2013·Journal of the Royal Society, Interface·Michaël J A GirardC Ross Ethier
Dec 5, 2013·Investigative Ophthalmology & Visual Science·Bo WangJoel S Schuman
Mar 13, 2014·Investigative Ophthalmology & Visual Science·Ali A HussainJohn Marshall
Apr 3, 2014·IEEE Transactions on Medical Imaging·I A SigalG Wollstein
Jun 18, 2014·The British Journal of Ophthalmology·Ian A SigalMichael J A Girard
Sep 18, 2014·Investigative Ophthalmology & Visual Science·Zach NadlerGadi Wollstein
Oct 7, 2014·Experimental Eye Research·Elizabeth C KimballHarry A Quigley
Mar 27, 2015·Journal of the Royal Society, Interface·H J JonesJ Albon
Jun 6, 2015·Investigative Ophthalmology & Visual Science·Sri Gowtham ThakkuMichael J A Girard
Dec 25, 2015·Experimental Eye Research·Lisa A Ostrin, Christine F Wildsoet
May 18, 2016·Investigative Ophthalmology & Visual Science·Baptiste CoudrillierC Ross Ethier
May 28, 2016·Biomedical Optics Express·Miao ZhangYali Jia
Aug 12, 2016·Eye and Vision·Charles WhitfordAhmed Elsheikh
Dec 6, 2016·Progress in Retinal and Eye Research·Zachary M DongJoel S Schuman
May 22, 2017·Experimental Eye Research·Andrew P VoorheesIan A Sigal
Jul 25, 2017·Investigative Ophthalmology & Visual Science·Christopher A GirkinJ Crawford Downs
Oct 20, 2017·Investigative Ophthalmology & Visual Science·Andrew P VoorheesIan A Sigal
Nov 22, 2017·PloS One·Bo WangGadi Wollstein
Feb 1, 2017·Proceedings of SPIE·H TranI A Sigal