Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head.

Investigative Ophthalmology & Visual Science
Huong TranIan A Sigal

Abstract

To introduce an experimental approach for direct comparison of the primate optic nerve head (ONH) before and after death by exsanguination. The ONHs of four eyes from three monkeys were imaged with spectral-domain optical coherence tomography (OCT) before and after exsanguination under controlled IOP. ONH structures, including the Bruch membrane (BM), BM opening, inner limiting membrane (ILM), and anterior lamina cribrosa (ALC) were delineated on 18 virtual radial sections per OCT scan. Thirteen parameters were analyzed: scleral canal at BM opening (area, planarity, and aspect ratio), ILM depth, BM depth; ALC (depth, shape index, and curvedness), and ALC visibility (globally, superior, inferior, nasal, and temporal quadrants). All four ALC quadrants had a statistically significant improvement in visibility after exsanguination (overall P < 0.001). ALC visibility increased by 35% globally and by 36%, 37%, 14%, and 4% in the superior, inferior, nasal, and temporal quadrants, respectively. ALC increased 4.1%, 1.9%, and 0.1% in curvedness, shape index, and depth, respectively. Scleral canals increased 7.2%, 25.2%, and 1.1% in area, planarity, and aspect ratio, respectively. ILM and BM depths averaged -7.5% and -55.2% decreases in d...Continue Reading

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Citations

Apr 10, 2020·Investigative Ophthalmology & Visual Science·Thanadet ChuangsuwanichMichaël J A Girard
Nov 10, 2020·Investigative Ophthalmology & Visual Science·Andrew P VoorheesIan A Sigal

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Software Mentioned

Matlab
R Language and Environment for Statistical Computing
R Foundation for Statistical Computing
FIJI

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