Segment-specific expression of connexin31 in the embryonic hindbrain is regulated by Krox20

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Stefan JungbluthJean Champagnat

Abstract

Communication and interaction between cells has been shown to be important during the embryonic development of the vertebrate hindbrain, which becomes transiently subdivided into segments called rhombomeres (r). One gene family allowing intercellular communication and possibly being involved in the control of hindbrain development is the connexin family encoding gap junction channels. Here, we have characterized in detail the previously observed (Dahl et al., 1997) expression of one particular connexin gene, connexin31 (Cx31), in the mouse embryonic hindbrain and compared it with that of Cx43 and Cx36. We found transient Cx31 expression from approximately embryonic day (E) E8-E11 in two small lateral/dorsal subgroups of cells in the hindbrain. We could show that these spots of expression corresponded to r3 and r5 and that Cx31 expression in r3 and r5 was controlled by the transcription factor Krox20. In contrast, expression of Cx43 and Cx36 started later (from E9.5 and E10.5, respectively) and was confined to longitudinal stripes of expression. In addition, from E10.5-E11.5, Cx31 was expressed by a column of cells in ventral r4, most likely representing contralateral vestibulo-acoustic efferent neurons, immediately anterior to ...Continue Reading

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Citations

Jan 28, 2006·Development Genes and Evolution·Iain M Dykes, Eduardo R Macagno
Aug 10, 2006·Cell and Tissue Research·Roberto Bruzzone, Rolf Dermietzel
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Charles K AbramsFeliksas F Bukauskas
Oct 11, 2015·Cell and Tissue Research·Abdulrahman RaslanCarola Meier
Dec 20, 2005·Biochimica Et Biophysica Acta·Masahito OyamadaTetsuro Takamatsu
Apr 25, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Kim E HaworthPaul T Sharpe
Jan 17, 2012·Biochimica Et Biophysica Acta·Masahito OyamadaYumiko Oyamada
Jan 29, 2005·Genomics·Curtis L AndersonRudolf Werner

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