Segmental Additive Tissue Engineering

Scientific Reports
Martina SladkovaGiuseppe Maria de Peppo

Abstract

Segmental bone defects caused by trauma and disease represent a major clinical problem worldwide. Current treatment options are limited and often associated with poor outcomes and severe complications. Bone engineering is a promising alternative solution, but a number of technical challenges must be addressed to allow for effective and reproducible construction of segmental grafts that meet the size and geometrical requirements needed for individual patients and routine clinical applications. It is important to devise engineering strategies and standard operating procedures that make it possible to scale up the size of bone-engineered grafts, minimize process and product variability, and facilitate technology transfer and implementation. To address these issues, we have combined traditional and modular tissue engineering approaches in a strategy referred to as Segmental Additive Tissue Engineering (SATE). To demonstrate this approach, a digital reconstruction of a rabbit femoral defect was partitioned transversally to the longitudinal axis into segments (modules) with discoidal geometry and defined thickness to enable protocol standardization and effective tissue formation in vitro. Bone grafts corresponding to each segment wer...Continue Reading

References

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Jun 22, 2017·Journal of Tissue Engineering and Regenerative Medicine·Martina SladkovaGiuseppe Maria de Peppo

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Citations

Nov 2, 2019·Annals of the New York Academy of Sciences·Edmund TamGiuseppe Maria de Peppo
Jan 24, 2020·Expert Opinion on Biological Therapy·Anna Julie PeiredElena Lazzeri
Jan 13, 2019·Stem Cell Research & Therapy·Madison McGrathGiuseppe Maria de Peppo
Jan 28, 2021·International Journal of Molecular Sciences·Giulia BattafaranoAndrea Del Fattore
Dec 19, 2020·Scientific Reports·Martina Sladkova-FaureGiuseppe Maria de Peppo

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Autodesk Inventor
Simpleware
AutoCAD
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Aperio ImageScope
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ASIPro [UNK]
ScanIP Simpleware
COMSOL Multiphysics

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