Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system

Nature
J M GreenbergT H Rabbits

Abstract

Although most proto-oncogenes such as c-myc are involved in cell proliferation, being expressed in a wide range of tissues as well as in progenitors of transformed cells, others may normally function in cellular differentiation. We now report on a gene on human chromosome 11, at the junction of the T-cell tumour-associated chromosomal translocation t(11; 14) (p15; q11) and known as the 11p15 gene or Ttg, which is believed to be involved in the pathogenesis of the tumour. It has two transcriptional promoters (both retained by the translocated allele) and is expressed in tumour cells with neuro-endocrine properties, suggesting that normal expression may occur in nerve cells. Using fusion constructs of one 11p15 promoter and lacZ in transgenic mice, we found that the gene is expressed in a segment-specific manner in rhombomeres of the developing mouse hind-brain. During subsequent development, the gene is more widely expressed, again in precisely defined regional patterns, but in post-mitotic neurons confined to the central nervous system. Thus, this presumptive T-cell oncogene is both developmentally regulated and segmentally restricted in a tissue different from that in which the original tumour arose.

References

Nov 1, 1987·Developmental Biology·A FainsodF H Ruddle
Jan 1, 1989·Annals of the New York Academy of Sciences·C KappenF H Ruddle
Oct 20, 1989·European Journal of Biochemistry·T Boehm, T H Rabbitts
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniR Levi-Montalcini
Jan 1, 1986·Annual Review of Genetics·A G Knudson
Nov 1, 1988·Trends in Genetics : TIG·T H RabbittsL Mengle-Gaw

❮ Previous
Next ❯

Citations

Jun 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T TakahashiT Nakamura
Jun 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M A Paradies, L M Eisenman
Oct 1, 1992·Molecular Reproduction and Development·M Cohen-TannoudjiC Babinet
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J M AngelE R Richie
Jan 1, 1995·Journal of Molecular Neuroscience : MN·R Hawkes, K Herrup
Oct 15, 1991·Cancer Genetics and Cytogenetics·M L SilvaR C Ribeiro
Aug 1, 1990·Trends in Neurosciences·D G Wilkinson, R Krumlauf
Dec 1, 1991·Trends in Neurosciences·M V Sofroniew, K Staley
Sep 1, 1991·Neuroscience Research·M Yamamoto, G Schwarting
Sep 1, 1994·Trends in Genetics : TIG·I Sánchez-García, T H Rabbitts
Apr 1, 1993·Neurochemistry International·M SudolP C Maisonpierre
Apr 14, 2006·Nature Reviews. Cancer·Clemens GrabherA Thomas Look
Mar 29, 2002·The European Journal of Neuroscience·Stephen KellyJames McCulloch
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C BonnerotJ F Nicolas
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T BoehmT H Rabbitts
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P M LiC T Walsh
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T BoehmT H Rabbitts
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N LeclercM Yamamoto
Dec 1, 1992·The Journal of Cell Biology·I SadlerM C Beckerle
Dec 14, 1990·Science·L Manuelidis
Mar 15, 2000·Reviews in the Neurosciences·M Bader
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·E Tse, T H Rabbitts
Aug 1, 1992·Leukemia & Lymphoma·R C RibeiroC H Pui
Oct 1, 1992·Baillière's Clinical Haematology·R Berger
Aug 7, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S KellyJ B Uney
Aug 7, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christelle MatisRené Rezsohazy
Aug 9, 2005·Brain Research. Molecular Brain Research·Sueli M Oba-ShinjoMari C Sogayar
Jun 26, 2015·Open Biology·Jennifer Chambers, Terence H Rabbitts
Mar 8, 2000·Mechanisms of Development·I Bach
Jun 5, 2013·Therapeutic Advances in Hematology·Valeria Tosello, Adolfo A Ferrando

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.