Segmental arterial mediolysis and fibromuscular dysplasia: what comes first, the chicken or the egg?

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
E Tyler HallBrandon T Larsen

Abstract

Segmental arterial mediolysis (SAM) is a rare vasculopathy characterized by lysis of the outer media in splanchnic arteries and formation of dissecting pseudoaneurysms that may spontaneously rupture, leading to massive and often fatal intraabdominal hemorrhage. The pathogenesis of SAM is poorly understood. Healed SAM lesions closely resemble fibromuscular dysplasia (FMD), leading some authors to postulate that SAM represents a precursor to FMD despite distinct clinical differences between these two disorders. Herein, we present a 61-year-old woman with fatal SAM who showed histologic features in her aorta suggesting the opposite pathogenetic relationship, with an unclassified "FMD-like" arteriopathy preceding development of SAM.

References

Nov 26, 2008·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Richard E Slavin

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Citations

Sep 3, 2016·Abdominal Radiology·Kinan AlhalabiSailendra Naidu
Feb 16, 2018·AJR. American Journal of Roentgenology·Sailen G NaiduRobert D McBane
Nov 16, 2018·Vascular Medicine·Thom Rooke
Dec 4, 2019·Vascular Medicine·Nedaa SkeikMary L Pavia
Jan 20, 2018·Journal of Vascular Surgery Cases and Innovative Techniques·Aude BelbezierLaurence Bouillet
Nov 26, 2019·Journal of Vascular Surgery·Kate X PengSamuel R Money

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