PMID: 9447610Feb 3, 1998Paper

Segmental distribution of muscle weakness in SMA III: implications for deterioration in muscle strength with time

Neuromuscular Disorders : NMD
F DeymeerC Ozdemir

Abstract

We examined 26 spinal muscular atrophy type III (SMA III) patients with SMNt deletions, searching for possible segmental distribution of muscle weakness. In those with disease duration of < or = 11 years, the weakest muscles were upper lumbar innervated ones in the lower extremities. In the upper extremities, early involvement of triceps muscle suggested the possibility of lower cervical (C7) onset. Electrophysiologically, weaker muscles had a more severe reduction in the recruitment pattern, particularly in the lower extremities. However, severe reduction in recruitment was sometimes also observed in clinically strong muscles. In patients with disease duration of > or = 16 years and regardless of disease duration, in those with disease onset at < or = 3 years of age, weakness and severe electrophysiological changes were more widespread. These findings may suggest a progression in muscle weakness with time. When compared to 12 patients with Becker muscular dystrophy (BMD), early stage SMA III with weak iliopsoas-strong gluteus maximus stood in contrast to BMD with weak gluteus maximus-strong iliopsoas.

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Citations

Jul 13, 2002·Muscle & Nerve·Luciano MerliniLucia Morandi
Dec 14, 2011·Journal of Child Neurology·Sally DunawayDarryl C De Vivo
Oct 12, 2010·Journal of Child Neurology·Douglas M SproulePetra Kaufmann
Mar 31, 2004·Muscle & Nerve·Luciano MerliniGiuseppe Vita
Oct 15, 2013·Muscle & Nerve·Jacqueline MontesAshwini K Rao
Oct 21, 2016·Muscle & Nerve·Sally Dunaway YoungDarryl C De Vivo
Jan 1, 2014·Muscle & Nerve·Sally DunawayDarryl C De Vivo
Nov 30, 2019·Journal of Neurology·Claudia BrognaEugenio Mercuri
Sep 15, 2020·Journal of Neuromuscular Diseases·Rafael Rodriguez-TorresJacqueline Montes

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