Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila.

Molecular Biology and Evolution
Oriol CalveteAlfredo Ruiz

Abstract

Chromosomal inversions are usually portrayed as simple two-breakpoint rearrangements changing gene order but not gene number or structure. However, increasing evidence suggests that inversion breakpoints may often have a complex structure and entail gene duplications with potential functional consequences. Here, we used a combination of different techniques to investigate the breakpoint structure and the functional consequences of a complex rearrangement fixed in Drosophila buzzatii and comprising two tandemly arranged inversions sharing the middle breakpoint: 2m and 2n. By comparing the sequence in the breakpoint regions between D. buzzatii (inverted chromosome) and D. mojavensis (noninverted chromosome), we corroborate the breakpoint reuse at the molecular level and infer that inversion 2m was associated with a duplication of a ~13 kb segment and likely generated by staggered breaks plus repair by nonhomologous end joining. The duplicated segment contained the gene CG4673, involved in nuclear transport, and its two nested genes CG5071 and CG5079. Interestingly, we found that other than the inversion and the associated duplication, both breakpoints suffered additional rearrangements, that is, the proximal breakpoint experience...Continue Reading

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Citations

Jan 8, 2013·Evolution; International Journal of Organic Evolution·Montserrat PapaceitMontserrat Aguadé
Jun 7, 2014·Frontiers in Genetics·Diego AyalaJosefa González
Jan 2, 2015·Genome Biology and Evolution·Yolanda GuillénAlfredo Ruiz
May 23, 2019·Genome Biology and Evolution·Vinicius H da SilvaMartien A M Groenen
May 22, 2020·Genome Biology and Evolution·Jakob McBroomeRussell Corbett-Detig
Oct 29, 2020·Proceedings. Biological Sciences·Mei LuoHenry Chung

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