Segmental effects on motor function following different intrathecal receptor agonists and antagonists in rabbits

Acta Anaesthesiologica Scandinavica
F M Borgbjerg, C Frigast

Abstract

The occurrence of motor impairment after intrathecal drug administration is infrequently reported in the literature and the methods of determining motor function vary. Motor function was examined in rabbits after a wide dose range of a variety of intrathecally administered opioid agonists, alpha-adrenergic agonists, non-competitive NMDA antagonists, a benzodiazepine agonist, a sigma agonist, paracetamol, isotonic and acidified saline. The opioids, sigma agonist and NMDA antagonists were additionally examined following pretreatment with naloxone. The opioid antagonists naltrindole and MR2266 (delta- and kappa-opioid receptor antagonists, respectively) were administered before the delta agonist and the kappa agonist. The alpha 2-adrenergic antagonist yohimbine was given before administration of dexmedetomidine and xylazine. Motor function was evaluated by a five-point scale of motor impairment ranging from normal function to total paralysis of the hindlegs. DPDPE (delta agonist), paracetamol, naloxone, naltrindole, yohimbine, isotonic and acidified saline did not affect motor function. MR2266 produced minor motor impairment. The alpha-adrenergic agonist dexmedetomidine reduced motor function slightly and dose independently. The r...Continue Reading

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Citations

Jun 17, 2004·American Journal of Veterinary Research·Joao Henrique N SoaresFirmino Marsico Filho
Jan 27, 2009·Acta Cirúrgica Brasileira·Leandro Guimarães FrancoLuiz Antônio Franco da Silva

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