Abstract
The occurrence of motor impairment after intrathecal drug administration is infrequently reported in the literature and the methods of determining motor function vary. Motor function was examined in rabbits after a wide dose range of a variety of intrathecally administered opioid agonists, alpha-adrenergic agonists, non-competitive NMDA antagonists, a benzodiazepine agonist, a sigma agonist, paracetamol, isotonic and acidified saline. The opioids, sigma agonist and NMDA antagonists were additionally examined following pretreatment with naloxone. The opioid antagonists naltrindole and MR2266 (delta- and kappa-opioid receptor antagonists, respectively) were administered before the delta agonist and the kappa agonist. The alpha 2-adrenergic antagonist yohimbine was given before administration of dexmedetomidine and xylazine. Motor function was evaluated by a five-point scale of motor impairment ranging from normal function to total paralysis of the hindlegs. DPDPE (delta agonist), paracetamol, naloxone, naltrindole, yohimbine, isotonic and acidified saline did not affect motor function. MR2266 produced minor motor impairment. The alpha-adrenergic agonist dexmedetomidine reduced motor function slightly and dose independently. The r...Continue Reading
References
Feb 1, 1979·Anesthesiology·J K WangJ E Thomas
Feb 25, 1992·European Journal of Pharmacology·J NäsströmC Post
Apr 1, 1992·Pain·J L PlummerM J Cousins
Jan 10, 1991·European Journal of Pharmacology·B FisherB M Peterson
Apr 1, 1990·Anesthesiology·S K ParkinsonJ B Mueller
Jul 5, 1991·Brain Research·C MiaskowskiJ D Levine
Jan 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Q T PalaciosT H Joyce
Nov 1, 1990·Pain·L JacobsonL Wasse
Apr 1, 1990·Neuropharmacology·A YanezT L Yaksh
Sep 1, 1987·British Journal of Anaesthesia·I D KlepperP R Bromage
Dec 1, 1987·Brain Research·R M Caudle, L Isaac
Jan 1, 1988·Pain·P MollenholtI Paulsson
Oct 1, 1988·Pain·Santi SpampinatoSergio Ferri
Nov 1, 1988·Acta Anaesthesiologica Scandinavica·T Gordh
Jan 1, 1988·Life Sciences·F M JensenA Christensen
Sep 1, 1973·Anesthesia and Analgesia·E G DowdyY Gocho
Nov 1, 1970·Neuropharmacology·A HerzH Teschemacher
Jul 22, 1983·European Journal of Pharmacology·A I Faden, T P Jacobs
Mar 30, 1981·Brain Research·C J Woolf
Dec 1, 1981·Pain·T L Yaksh
Oct 1, 1984·Anaesthesia·J F Bion
Sep 1, 1995·Anesthesia and Analgesia·I Acalovschi, T Cristea
May 1, 1995·Anaesthesia·D A HillI M Bali
Nov 1, 1994·British Journal of Anaesthesia·D GraceJ P Fee
Jan 1, 1995·Anesthesiology·S B GroudineP D Lumb
Jan 1, 1994·Pain·J D KristensenO G Berge
Jun 1, 1993·British Journal of Anaesthesia·M E CrawfordJ B Madsen
May 12, 1993·European Journal of Pharmacology·P J Tiseo, T L Yaksh
Apr 1, 1993·Acta Anaesthesiologica Scandinavica·J B MadsenV Bille-Hansen
Feb 1, 1996·Pain·C Glynn, K O'Sullivan
Jan 1, 1996·Acta Anaesthesiologica Scandinavica·S M Fernandez-GalinskiM M Puig
Citations
Jun 17, 2004·American Journal of Veterinary Research·Joao Henrique N SoaresFirmino Marsico Filho
Mar 15, 2012·Veterinary Anaesthesia and Analgesia·Andreas LervikClaudia Spadavecchia
Apr 15, 2014·Veterinary Surgery : VS·Yael ChamishaOrit Chai
Jan 27, 2009·Acta Cirúrgica Brasileira·Leandro Guimarães FrancoLuiz Antônio Franco da Silva