Abstract
In order to identify the oncogene associated with malignant transformation 141 leukemia and malignant lymphoma patients were studied by FISH. Specific chromosome regions were translocated onto structurally abnormal chromosomes, resulting in partial tri-, tetra-, or pentasomy of these regions. We designated this type of chromosomal translocation as a "segmental jumping translocation (SJT)". These SJTs were found in several chromosomal regions such as 8q24, 9q34, 11q13, 11q23, 13q14, 14q24-q32, 21q22 and 22q11. The SJT at 9q34, which involved the ABL oncogene, was found in three of nine secondary leukemia patients who were treated with anticancer drugs and radiation. Non-Hodgkin's lymphoma and acute myeloid leukemia (AML) patients had 3-7 copies of SJT at 11q13 or 11q23. SJT at 14q32 and 21q22 were predominantly detected in the acute type of adult T-cell leukemia (8 of 27 patients) and in AML (5 of 17 patients). The size of the SJT regions varied among the patients. The overlapping region within the SJT could involve oncogene(s) associated with transformation to the advanced stage in leukemia and lymphoma patients. The SJT provides evidence of a new mechanism for gene amplification and formation of unidentified marker chromosomes...Continue Reading
References
Mar 1, 1979·Journal of Neurochemistry·M Iwamori, Y Nagai
May 1, 1992·Genomics·T HoriY Nakamura
Aug 1, 1992·Genomics·M EmiY Nakamura
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G Kovacs, H F Kung
Feb 1, 1991·Cancer Genetics and Cytogenetics·M D ReisJ S Senn
Apr 1, 1990·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·M Mody, J Nagai
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D D Von HoffG M Wahl
Mar 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M M Le BeauJ D Rowley
May 1, 1983·American Journal of Clinical Pathology·J W VardimanJ Rowley
Dec 2, 1982·The New England Journal of Medicine·M H GreeneA J Dembo
Mar 1, 1995·Genes, Chromosomes & Cancer·M BentzP Lichter
Jul 1, 1995·Cancer Genetics and Cytogenetics·E NachevaA R Green
Oct 1, 1993·Mutation Research·F CortésT Ortiz
Mar 1, 1995·Cancer Genetics and Cytogenetics·L SeghezziE Maserati
Oct 1, 1994·Nature Genetics·X Y GuanJ M Trent
Sep 1, 1994·Cancer Genetics and Cytogenetics·I WlodarskaH Van Den Berghe
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·W P Stemmer
Nov 1, 1993·Cancer Genetics and Cytogenetics·T ShikanoY Ishikawa
Citations
Apr 3, 2001·Genes, Chromosomes & Cancer·M K AndersenJ Pedersen-Bjergaard
Sep 22, 2001·Cancer Genetics and Cytogenetics·K S ReddyJ A Chan
May 30, 2002·Cancer Genetics and Cytogenetics·Michelle DolanBetsy Hirsch
Mar 25, 2000·Cancer Genetics and Cytogenetics·D FalzettiC Mecucci
May 17, 2000·Cancer Genetics and Cytogenetics·K TanakaN Kamada
Jul 28, 2009·BMC Genomics·Mark S LongoRachel J O'Neill
Mar 10, 2001·Genes, Chromosomes & Cancer·H M Padilla-NashT Ried
Jul 31, 2001·Genes, Chromosomes & Cancer·C FonatschK Lechner
May 18, 2010·Cancer Genetics and Cytogenetics·Iveta SárováKyra Michalová
Jul 9, 2003·Immunological Reviews·Kevin D MillsFrederick W Alt
Dec 21, 2005·Cancer Genetics and Cytogenetics·Irén HaltrichStefan Imreh
Feb 1, 2003·Cancer Cell·Rebecca A GladdyJayne S Danska
Oct 3, 2003·Leukemia·J I Martín-SuberoR Siebert
Feb 24, 2004·Genes, Chromosomes & Cancer·Andrea ZatkovaKatharina Wimmer
Apr 21, 2007·Genes, Chromosomes & Cancer·Roland Berger, Olivier A Bernard
Jan 19, 2000·Leukemia·M BernardT Lamy