Segmentation and Classification in Digital Pathology for Glioma Research: Challenges and Deep Learning Approaches

Frontiers in Neuroscience
Tahsin M KurcKeyvan Farahani

Abstract

Biomedical imaging Is an important source of information in cancer research. Characterizations of cancer morphology at onset, progression, and in response to treatment provide complementary information to that gleaned from genomics and clinical data. Accurate extraction and classification of both visual and latent image features Is an increasingly complex challenge due to the increased complexity and resolution of biomedical image data. In this paper, we present four deep learning-based image analysis methods from the Computational Precision Medicine (CPM) satellite event of the 21st International Medical Image Computing and Computer Assisted Intervention (MICCAI 2018) conference. One method Is a segmentation method designed to segment nuclei in whole slide tissue images (WSIs) of adult diffuse glioma cases. It achieved a Dice similarity coefficient of 0.868 with the CPM challenge datasets. Three methods are classification methods developed to categorize adult diffuse glioma cases into oligodendroglioma and astrocytoma classes using radiographic and histologic image data. These methods achieved accuracy values of 0.75, 0.80, and 0.90, measured as the ratio of the number of correct classifications to the number of total cases, w...Continue Reading

References

Jan 1, 2009·IEEE Reviews in Biomedical Engineering·Metin N GurcanB Yener
Jan 7, 2011·Journal of Chemical Information and Modeling·Georg HinselmannAndreas Zell
Sep 29, 2011·IEEE Transactions on Bio-medical Engineering·Jun KongDaniel J Brat
Jan 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philippe LambinHugo J W L Aerts
Jul 26, 2013·Journal of Digital Imaging·Kenneth ClarkFred Prior
Aug 21, 2013·Journal of the American Medical Informatics Association : JAMIA·Sonal KothariMay D Wang
Jun 4, 2014·Nature Communications·Hugo J W L AertsPhilippe Lambin
Dec 11, 2014·IEEE Transactions on Medical Imaging·Bjoern H MenzeKoen Van Leemput
Feb 19, 2015·Contemporary Oncology Współczesna Onkologia·Katarzyna TomczakMaciej Wiznerowicz
Mar 10, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Thibaud P CorollerHugo J W L Aerts
Aug 19, 2015·Scientific Reports·Chintan ParmarHugo J W L Aerts
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jun 28, 2016·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Yan YuanFaith G Davis
Jul 18, 2016·Medical Image Analysis·Anant Madabhushi, George Lee
Dec 14, 2016·Histopathology·Jon Griffin, Darren Treanor
Apr 5, 2017·Journal of Digital Imaging·Linda C KelahanRoss W Filice
Apr 22, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Spyridon BakasChristos Davatzikos
Aug 27, 2017·Chinese Clinical Oncology·Gaurav ShuklaWenyin Shi
Nov 3, 2017·Cancer Research·Joost J M van GriethuysenHugo J W L Aerts
Nov 24, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ken ChangJayashree Kalpathy-Cramer
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Pooya MobadersanyLee A D Cooper
Oct 1, 2012·ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine·Sonal KothariMay D Wang
Apr 5, 2018·Journal of the American Medical Informatics Association : JAMIA·Ken ChangJayashree Kalpathy-Cramer
May 10, 2018·Scientific Reports·Mohammad PeikariAnne L Martel
Jun 18, 2018·International Journal of Radiation Oncology, Biology, Physics·Sean D McGarryPeter S LaViolette
Dec 12, 2018·IEEE Journal of Biomedical and Health Informatics·Qi QiGustavo Kunde Rohde
Jan 3, 2019·Journal of Pathology and Translational Medicine·Hye Yoon ChangTae-Yeong Kwak
Apr 20, 2019·Frontiers in Bioengineering and Biotechnology·Quoc Dang VuKeyvan Farahani

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Citations

Nov 4, 2020·Cellular & Molecular Immunology·Sterre T PaijensHans W Nijman
May 8, 2021·British Journal of Cancer·Gagandeep SinghVadim Spektor
May 14, 2021·Frontiers in Oncology·Emilie DarriguesAnaliz Rodriguez

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Methods Mentioned

BETA
feature extractor
feature extraction
biopsy

Software Mentioned

NMS
Matterport
Mask
pyradiomic
Unet
CNN
DenseNet
ImCalc
TCGA
SPM12

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