Segmentation and volumetric analysis of the caudate nucleus in Alzheimer's disease

European Journal of Radiology
Sudevan JijiRamapurath S Jayasree


A quantitative volumetric analysis of caudate nucleus can provide valuable information in early diagnosis and prognosis of patients with Alzheimer's diseases (AD). Purpose of the study is to estimate the volume of segmented caudate nucleus from MR images and to correlate the variation in the segmented volume with respect to the total brain volume. We have also tried to evaluate the caudate nucleus atrophy with the age related atrophy of white matter (WM), gray matter (GM) and cerebrospinal fluid (CSF) in a group of Alzheimer's disease patients. 3D fast low angle shot (3D FLASH) brain MR images of 15 AD patients, 15 normal volunteers and 15 patients who had normally diagnosed MR images were included in the study. Brain tissue and caudate nuclei were segmented using the statistical parametric mapping package and a semi-automatic tool, respectively and the volumes were estimated. Volume of segmented caudate nucleus is correlated with respect to the total brain volume. Further, the caudate nucleus atrophy is estimated with the age related atrophy of WM, GM and CSF in a group of AD patients. Significant reduction in the caudate volume of AD patients was observed compared to that of the normal volunteers. Statistical analysis also sh...Continue Reading


May 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·B DeweerB Dubois
Dec 28, 1999·Alzheimer Disease and Associated Disorders·D S WolfS S Mirra
May 12, 2000·Neuroscience Letters·S A RomboutsP Scheltens
Oct 9, 2002·JAMA : the Journal of the American Medical Association·F Xavier CastellanosJudith L Rapoport
Feb 26, 2003·Annals of Neurology·Rebecca S N LiuJohn S Duncan
Jun 5, 2003·Dementia and Geriatric Cognitive Disorders·Osvaldo P AlmeidaJohn T O'Brien
Aug 9, 2005·NeuroImage·Matthias J MüllerAndreas Fellgiebel
Jun 7, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·S E RoseJ B Chalk
Aug 2, 2008·Brain : a Journal of Neurology·Peita D BruenAnnalena Venneri
Nov 22, 2008·Brain : a Journal of Neurology·L W de JongJ van der Grond
Aug 7, 2009·Computer Methods in Biomechanics and Biomedical Engineering·Zhen MaT Mascarenhas
Jun 12, 2010·Neurobiology of Aging·S K MadsenAlzheimer's Disease Neuroimaging Initiative
Sep 11, 2012·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Laura IgualPetia Radeva


Jan 24, 2016·Bioinformatics·Lei DuAlzheimer’s Disease Neuroimaging Initiative
Nov 22, 2014·Brain Imaging and Behavior·Nadine A SchwabCatherine C Price
Jan 13, 2015·Psychiatry Research·Ayse DonduCengiz Tataroglu
Dec 3, 2016·Journal of Alzheimer's Disease : JAD·Tanya GlozmanAlzheimer’s Disease Neuroimaging Initiative
Mar 23, 2017·IEEE Transactions on Medical Imaging·Ali-Reza Mohammadi-NejadHamid Soltanian-Zadeh
Jul 26, 2017·Acta Neurologica Scandinavica·K PerssonK Engedal
Apr 21, 2018·Journal of Magnetic Resonance Imaging : JMRI·Fenglian ZhengJianfeng Qiu
Sep 12, 2017·Alzheimer Disease and Associated Disorders·Matteo De MarcoAnnalena Venneri
Dec 2, 2017·AJNR. American Journal of Neuroradiology·A MeijermanAlzheimer's Disease Neuroimaging Initiative
Jul 20, 2018·Alzheimer Disease and Associated Disorders·Xiuqin JiaKuncheng Li
Apr 15, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Shania M SomanRamapurath S Jayasree
Feb 25, 2018·Journal of Prosthodontic Research·Takuya KobayashiHisatomo Kondo
May 28, 2019·Frontiers in Aging Neuroscience·Valentina PergherMarc M Van Hulle
May 17, 2019·Bioinformatics·Meiyan HuangAlzheimer’s Disease Neuroimaging Initiative
Dec 26, 2018·NeuroImage. Clinical·Meiyan HuangAlzheimer's Disease Neuroimaging Initiative

Related Concepts

Familial Alzheimer Disease (FAD)
Caudate Nucleus Structure
Image Enhancement
Image Interpretation, Computer-Assisted
Magnetization Transfer Contrast Imaging
Pattern Recognition System
Intraobserver Variation
Imaging, Three-Dimensional, Computer Assisted
Alzheimer's Disease

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