Segmentectomy versus lobectomy in early non-small cell lung cancer of 2 cm or less in size: A population-based study

Respirology : Official Journal of the Asian Pacific Society of Respirology
Mi Hyoung MoonSeok Whan Moon

Abstract

Standard surgical management for early stage lung cancer is lobectomy with mediastinal lymph node dissection. The feasibility of limited resection remains controversial; we retrospectively assessed lung cancer-specific survival (LCSS) and overall survival (OS) in early stage non-small cell lung cancer (NSCLC) to evaluate whether segmentectomy is comparable to standard lobectomy. Patients with primary NSCLC of 20 mm or less who were diagnosed from 2000 to 2014 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. To compare the two surgical interventions, a propensity score analysis was performed between lobectomy and segmentectomy. Of the 15 358 patients analysed, there were 14 549 lobectomies and 809 segmentectomies. The 5-year OS was 76% for the lobectomy group and 74.4% for the segmentectomy group. There were no significant differences in OS or LCSS among patients who underwent lobectomy versus segmentectomy, as demonstrated by the propensity-matched hazard ratio (HR) for OS (HR: 1.195, 95% CI: 0.993-1.439) and LCSS (HR: 1.124, 95% CI: 0.860-1.469). The inverse propensity-weighted analysis also supported these results. Segmentectomy was more likely to be performed in elderly patients. In the su...Continue Reading

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Citations

May 12, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Phan Nguyen
Jun 10, 2019·Interactive Cardiovascular and Thoracic Surgery·Waseem LutfiOlugbenga T Okusanya
Jun 20, 2019·Journal of Oncology·Maria Teresa CongedoStefano Margaritora
Feb 18, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Francesca M ConwayPallav L Shah
Dec 29, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Han WuHecheng Li
Apr 11, 2021·The Annals of Thoracic Surgery·Nicolas ZhouDavid C Rice

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