Segmented filamentous bacteria-induced immune responses: a balancing act between host protection and autoimmunity

Immunology
Kyle L Flannigan, Timothy L Denning

Abstract

Segmented filamentous bacteria (SFB) are Gram-positive, spore-forming, bacteria that primarily colonize the ileum of the small intestine. Upon direct adherence to intestinal epithelial cells, SFB actively stimulate innate and adaptive immune cell activation. The cardinal features of SFB-induced gut immunity - T helper type 17 (Th17) cell differentiation, IgA production and barrier protection - lead to the containment of SFB and further afford protection against invading pathogens. Th17 cells and interleukin-17A, however, can also reach peripheral sites and exacerbate autoimmunity. In this review, we highlight salient characteristics of SFB-host interactions and detail the cellular and molecular immune mechanisms involved in coordinating these responses.

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Citations

Feb 24, 2019·Nature Reviews. Nephrology·Felix KnaufRichard A Flavell
Jul 13, 2019·Cells·Bruno LucchinoManuela Di Franco
Dec 12, 2019·Frontiers in Immunology·Yanling WangCharlie Xiang
Feb 12, 2021·Nature Reviews. Immunology·Kelsey E HuusB Brett Finlay
Nov 19, 2020·Journal of Immunology Research·Yuan HuangYueyun Ma
Jun 17, 2021·Immunology·Annika Frede, Simon Milling
Aug 8, 2021·International Journal of Molecular Sciences·Sung-Min WonKi-Tae Suk
Oct 17, 2021·Expert Review of Gastroenterology & Hepatology·Shaghayegh Baradaran GhavamiMassoud Vosough

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