PMID: 9169557Jun 1, 1997Paper

Segmented gene conversion as a mechanism of correction of 18S rRNA pseudogene located outside of rDNA cluster in D. melanogaster

Journal of Molecular Evolution
E V BenevolenskayaV A Gvozdev

Abstract

The peculiarities of the sequences of 18S rDNA included in a 90-kb DNA segment cloned in YAC vector are described. This heterochromatic segment is situated on the X chromosome distal to the main rDNA cluster. The pseudo 18S rDNA sequence comprised undamaged stretches of rDNA interspersed with segments characterized by high density of nucleotide substitutions and insertions/deletions. The observed patchwork arrangement of unaltered rDNA sequences was considered as evidence of segmented gene conversion events between the normal and damaged genes which are thought to constitute one of the mechanisms of rDNA array homogenization. The 18S rDNA fragment (510 bp) located nearby, homologous to the internal, undamaged part of pseudo 18S rDNA, carries comparable density of randomly distributed nucleotide substitutions with no evidence of correction.

Citations

Mar 30, 2011·Molecular Biology and Evolution·Juan S EscobarNicolas Galtier
May 10, 2003·Proceedings. Biological Sciences·Isabelle Schön, Koen Martens
Mar 23, 2011·Genome Génome / Conseil National De Recherches Canada·Dmitry V MukhaCoby Schal
Apr 8, 2009·Molecular Phylogenetics and Evolution·Jianpeng XuJie Qi
Nov 18, 2003·Annual Review of Genetics·Evgeniy S Balakirev, Francisco J Ayala
Jan 13, 2006·Journal of Evolutionary Biology·I SchaeferM Maraun
Feb 4, 1999·Annals of the New York Academy of Sciences·D SharonD Lancet
Jan 13, 2006·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·D V MukhaC Schal
Jan 22, 2004·The Journal of Eukaryotic Microbiology·Scott R SantosMary Alice Coffroth

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