Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees

Genetic Epidemiology
J GrahamG P Jarvik

Abstract

Goals of this analysis were to map loci contributing to variation in the quantitative trait, Q1, using the lod-score method on data set 1, and to explore the difference in power to map genes when considering the discrete vs. quantitative phenotype. Segregation analyses, after covariate adjustment, correctly suggested two contributing loci. The major gene on chromosome 5 was successfully mapped, but the major gene on chromosome 8 was not. Comparison of linkage analyses for the qualitative and quantitative traits confirmed that the quantitative trait is more informative, suggesting that localizing disease genes with a qualitative trait would be more difficult in these pedigrees.

References

Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M LathropJ Ott
Jan 1, 1995·Genetic Epidemiology·J N Bailey, L Almasy

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Citations

Feb 21, 2004·BMC Genetics·Ellen L GoodeUNKNOWN Framingham Heart Study
Dec 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robert P IgoEllen M Wijsman

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