Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling.

Science
Benjamin W GallardaTill Marquardt

Abstract

Execution of motor behaviors relies on circuitries effectively integrating immediate sensory feedback to efferent pathways controlling muscle activity. It remains unclear how, during neuromuscular circuit assembly, sensory and motor projections become incorporated into tightly coordinated, yet functionally separate pathways. We report that, within axial nerves, establishment of discrete afferent and efferent pathways depends on coordinate signaling between coextending sensory and motor projections. These heterotypic axon-axon interactions require motor axonal EphA3/EphA4 receptor tyrosine kinases activated by cognate sensory axonal ephrin-A ligands. Genetic elimination of trans-axonal ephrin-A --> EphA signaling in mice triggers drastic motor-sensory miswiring, culminating in functional efferents within proximal afferent pathways. Effective assembly of a key circuit underlying motor behaviors thus critically depends on trans-axonal signaling interactions resolving motor and sensory projections into discrete pathways.

References

Jan 1, 1981·Applied Neurophysiology·J C Eccles
Jan 8, 1999·Brain Research. Developmental Brain Research·A GramsbergenL A van Eykern
May 26, 1999·Journal of Neuroscience Research·Z DongK R Jessen
Mar 20, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L T Landmesser
Feb 21, 2003·Current Opinion in Neurobiology·Hsiao-Huei ChenEric Frank
Oct 31, 2003·Molecular and Cellular Biology·Ashish VaidyaArthur Brown
Sep 15, 2004·Current Opinion in Cell Biology·Rüdiger Klein
Feb 22, 2005·Current Opinion in Neurobiology·Martyn Goulding, Samuel L Pfaff
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lely A QuinaEric E Turner
Jun 17, 2006·Annual Review of Neuroscience·Ole Kiehn
Oct 30, 2007·Neuron·Liqun Luo, John G Flanagan

❮ Previous
Next ❯

Citations

Sep 28, 2010·Annals of Biomedical Engineering·A G VoyiadjisT Shinbrot
Jan 28, 2012·Nature Protocols·Liang Wang, Till Marquardt
Jan 1, 2014·Nature Reviews. Drug Discovery·Andrew W BoydMartin Lackmann
Mar 17, 2009·Human Molecular Genetics·Sergio E BaranziniMichael R Barnes
Mar 20, 2010·Cold Spring Harbor Perspectives in Biology·Dario Bonanomi, Samuel L Pfaff
Jul 2, 2010·Cold Spring Harbor Perspectives in Biology·Jonathan Raper, Carol Mason
Mar 13, 2012·Development, Growth & Differentiation·Takeshi Imai
Jul 11, 2009·Science·Takeshi ImaiHitoshi Sakano
Nov 21, 2008·PloS One·Chrisantha FernandoEörs Szathmáry
Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stéphane NédelecHynek Wichterle
Jan 20, 2010·Journal of Visualized Experiments : JoVE·Allyn MeyerWilliam Alaynick
Mar 5, 2011·Journal of Visualized Experiments : JoVE·Suresh GarudadriWilliam Alaynick
Aug 7, 2013·Cellular and Molecular Life Sciences : CMLS·Aref Arzan ZarinJuan-Pablo Labrador
Mar 28, 2013·Neural Plasticity·Mitsuaki NishikimiKazunori Nakajima
Dec 29, 2011·Cellular and Molecular Life Sciences : CMLS·Eva NievergallPeter W Janes
Dec 3, 2014·Developmental Biology·Samantha J Butler, Marianne E Bronner
Apr 1, 2015·The Journal of Cell Biology·Dominique SiegenthalerJan Pielage
Nov 2, 2011·Seminars in Cell & Developmental Biology·Tzu-Jen KaoArtur Kania
Jun 2, 2015·Experimental Neurology·Stefan Wiese, Andreas Faissner
Dec 17, 2008·The Journal of Comparative Neurology·Marie-Eve TremblayGuy Doucet
Jun 10, 2011·Developmental Neurobiology·Valerie HigenellEdward S Ruthazer
Nov 23, 2011·The European Journal of Neuroscience·Takeshi Imai, Hitoshi Sakano
Jun 12, 2010·Annals of the New York Academy of Sciences·Benjamin W GallardaWilliam A Alaynick
Sep 24, 2015·Annual Review of Cell and Developmental Biology·Catarina CatelaJeremy S Dasen
Jul 23, 2011·Developmental Biology·Jane A CoxMark M Voigt
Nov 22, 2014·Growth Factors·Nenad TomasevicChristopher Bebbington
Nov 14, 2014·Growth Factors·Peter W JanesMary E Vail
Apr 12, 2008·Science·Keith K Murai, Elena B Pasquale
Aug 27, 2013·Current Opinion in Neurobiology·Liang Wang, Till Marquardt
Oct 7, 2009·Cell·Jason W TriplettDavid A Feldheim
Sep 24, 2013·Developmental Biology·Maëva LuxeyAlice Davy
Oct 28, 2014·Frontiers in Cellular Neuroscience·Nicolas Stifani
May 12, 2009·Current Topics in Developmental Biology·Jeremy S Dasen
Jun 27, 2018·Wiley Interdisciplinary Reviews. Developmental Biology·Michelle M Frank, Lisa V Goodrich
Jul 18, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chih-Ju ChangTzu-Jen Kao
Aug 17, 2012·Nature Reviews. Neuroscience·R Jeroen Pasterkamp
Jul 28, 2020·International Journal of Molecular Sciences·Olivia Spead, Fabienne E Poulain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.