Segregation of dopamine and glutamate release sites in dopamine neuron axons: regulation by striatal target cells

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Guillaume M FortinLouis-Eric Trudeau

Abstract

Dopamine (DA) is a key regulator of circuits controlling movement and motivation. A subset of midbrain DA neurons has been shown to express the vesicular glutamate transporter (VGLUT)2, underlying their capacity for glutamate release. Glutamate release is found mainly by DA neurons of the ventral tegmental area (VTA) and can be detected at terminals contacting ventral, but not dorsal, striatal neurons, suggesting the possibility that target-derived signals regulate the neurotransmitter phenotype of DA neurons. Whether glutamate can be released from the same terminals that release DA or from a special subset of axon terminals is unclear. Here, we provide in vitro and in vivo data supporting the hypothesis that DA and glutamate-releasing terminals in mice are mostly segregated and that striatal neurons regulate the cophenotype of midbrain DA neurons and the segregation of release sites. Our work unveils a fundamental feature of dual neurotransmission and plasticity of the DA system.-Fortin, G. M., Ducrot, C., Giguère, N., Kouwenhoven, W. M., Bourque, M.-J., Pacelli, C., Varaschin, R. K., Brill, M., Singh, S., Wiseman, P. W., Trudeau, L.-E. Segregation of dopamine and glutamate release sites in dopamine neuron axons: regulation by...Continue Reading

References

Sep 1, 1969·Journal of Neurochemistry·S FahnL J Côté
Sep 21, 2000·The European Journal of Neuroscience·M J Bourque, L E Trudeau
Jul 19, 2002·Journal of Neurochemistry·Natsuki MatsushitaKazuto Kobayashi
Feb 6, 2004·Progress in Neurobiology·Rafael Gutiérrez
Mar 15, 2005·Journal of Neuroscience Methods·Xiaoxi ZhuangRené Hen
Nov 29, 2007·Brain Research Reviews·Laurent DescarriesLouis-Eric Trudeau
Mar 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica A ShuenNicole Calakos
Jun 20, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jose Alfredo MendezLouis-Eric Trudeau
Jun 28, 2008·Pharmacology, Biochemistry, and Behavior·Bonnie Sonnenschein, Keith B J Franklin
Jul 18, 2008·Current Protocols in Neuroscience·Caroline FasanoLouis-Eric Trudeau
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tianxiang ZhangJohn A Dani
Oct 22, 2009·The Journal of Comparative Neurology·Noémie Bérubé-CarrièreLaurent Descarries
Nov 12, 2009·The Journal of Biological Chemistry·Etienne A CartierGonzalo E Torres
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carolina BirgnerAsa Wallén-Mackenzie
Dec 19, 2009·The Journal of Comparative Neurology·Paul M ForlanoAndrew H Bass
Feb 13, 2010·The Journal of Comparative Neurology·Paul M Forlano, Catherine S Woolley
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fatuel TecuapetlaTibor Koos
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bibiana OnoaRobert H Edwards
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Garret D StuberAntonello Bonci
Mar 19, 2011·Nature Reviews. Neuroscience·Salah El MestikawyLouis-Eric Trudeau
Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Antoine G GodinPaul W Wiseman
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tsuyoshi YamaguchiMarisela Morales
Jul 13, 2011·Neuron·Ofer YizharKarl Deisseroth
Sep 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johan AlsiöAsa Wallén-Mackenzie
Nov 8, 2011·Annual Review of Physiology·Thomas S Hnasko, Robert H Edwards
Sep 26, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·J Paul Bolam, Eleftheria K Pissadaki
Oct 5, 2012·Nature·Nicolas X TritschBernardo L Sabatini
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guillaume M FortinLouis-Éric Trudeau
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seth D DePuyPatrice G Guyenet
Sep 24, 2013·Nature Neuroscience·Sonia JegoAntoine R Adamantidis
Feb 28, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martín F AdroverVeronica A Alvarez
Jun 28, 2014·Progress in Brain Research·Louis-Eric TrudeauDavid Sulzer
Feb 11, 2015·Nature Neuroscience·Shiliang ZhangMarisela Morales
Jul 14, 2017·ELife·Susana MingoteStephen Rayport
Jan 18, 2018·The Journal of Clinical Investigation·Thomas SteinkellnerThomas S Hnasko

❮ Previous
Next ❯

Citations

Feb 26, 2020·PLoS Genetics·Lewis M ShererSarah J Certel
Jan 9, 2019·Frontiers in Neural Circuits·Louis-Eric Trudeau, Salah El Mestikawy
Apr 12, 2019·Frontiers in Neural Circuits·John Apergis-SchouteErik Svensson
Jun 24, 2019·Steroids·Todd L StincicMartin J Kelly
Nov 17, 2020·Current Opinion in Neurobiology·Talia N LernerJillian L Seiler
Jun 8, 2021·Frontiers in Neural Circuits·Daniel EskenaziNao Chuhma
Jul 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles DucrotLouis-Eric Trudeau

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.