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Segregation of mitochondrial genomes in a heteroplasmic lineage with Leber hereditary optic neuroretinopathy

American Journal of Human Genetics

Jul 1, 1990

J VilkkiE Nikoskelainen

PMID: 1971999

Abstract

Relatively little is known about the factors maintaining mitochondrial DNA (mtDNA) sequence diversity in humans. A detailed understanding of the transmission genetics of mtDNA has been partly hampered by the lack of evidence for heteroplasmic individuals. Among families with Leber hered...read more

Mentioned in this Paper

Optic Atrophies, Hereditary
Restriction Fragment Length Polymorphism
Hereditary, Type VII, Motor and Sensory Neuropathy
DNA, Mitochondrial
Optic Atrophy, Hereditary, Leber
Nucleotides
Oligoribonucleotide Probes
Mitochondrial DNA Location
Phenotype Determination
Mutation Abnormality
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Segregation of mitochondrial genomes in a heteroplasmic lineage with Leber hereditary optic neuroretinopathy

American Journal of Human Genetics

Jul 1, 1990

J VilkkiE Nikoskelainen

PMID: 1971999

DOI:

Abstract

Relatively little is known about the factors maintaining mitochondrial DNA (mtDNA) sequence diversity in humans. A detailed understanding of the transmission genetics of mtDNA has been partly hampered by the lack of evidence for heteroplasmic individuals. Among families with Leber hered...read more

Mentioned in this Paper

Optic Atrophies, Hereditary
Restriction Fragment Length Polymorphism
Hereditary, Type VII, Motor and Sensory Neuropathy
DNA, Mitochondrial
Optic Atrophy, Hereditary, Leber
Nucleotides
Oligoribonucleotide Probes
Mitochondrial DNA Location
Phenotype Determination
Mutation Abnormality

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